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Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563)


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Tested Data
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in ELISA
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in ELISA
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in WB
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in WB
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in WB
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in WB
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in FC
Mouse Anti-CLDN6 Recombinant Antibody (CBT2445) (V2LY-0625-LY1563) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2445
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CLDN6 (AA: extra(29-81) and extra(138-160)) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
9074
UniProt ID
P56747
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-160
Helical: 161-181
Cytoplasmic: 182-220
More Infomation

Matsuzaki, J., Lele, S., Odunsi, K., & Tsuji, T. (2022). Identification of Claudin 6-specific HLA class I-and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer. Oncoimmunology, 11(1), 2020983.

Du, H., Yang, X., Fan, J., & Du, X. (2021). Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation. Molecular Medicine Reports, 24(3), 1-9.

Gao, P., Peng, T., Cao, C., Lin, S., Wu, P., Huang, X., ... & Wu, P. (2021). Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. Frontiers in Genetics, 12.

Kojima, M., Sugimoto, K., Tanaka, M., Endo, Y., Kato, H., Honda, T., ... & Chiba, H. (2020). Prognostic significance of aberrant claudin-6 expression in endometrial cancer. Cancers, 12(10), 2748.

Kojima, M., Sugimoto, K., Kobayashi, M., Ichikawa-Tomikawa, N., Kashiwagi, K., Watanabe, T., ... & Chiba, H. (2021). Aberrant Claudin-6–Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α. Molecular Cancer Research.

Kohmoto, T., Masuda, K., Shoda, K., Takahashi, R., Ujiro, S., Tange, S., ... & Imoto, I. (2020). Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer. Gastric Cancer, 23(3), 403-417.

Lewis, J. B., Bodine, J. S., Gassman, J. R., Muñoz, S. A., Milner, D. C., Dunaway, T. M., ... & Reynolds, P. R. (2018). Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation. Environmental Science and Pollution Research, 25(18), 18179-18188.

Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X., ... & Quan, C. (2017). Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncology reports, 38(2), 875-885.

Bekki, H., Yamamoto, H., Takizawa, K., Iwasaki, T., Otsuka, H., Yamada, Y., ... & Oda, Y. (2017). Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. Pathology-Research and Practice, 213(6), 674-679.

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For research use only. Not intended for any clinical use.

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