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CSNK1G2

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are FoxO family signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.

Full Name

casein kinase 1, gamma 2

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Biological Process

Endocytosis Source: GO_Central
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: Reactome
Wnt signaling pathway Source: GO_Central

Cellular Location

Cytoplasm; Cell cortex

PTM

Autophosphorylated (PubMed:18794808). Phosphorylated by aPKC which promotes dissociation from the cell cortex (PubMed:26481050).

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Anti-CSNK1G2 antibodies

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Mouse Anti-CSNK1G2 Recombinant Antibody (CBYY-C2185) (CBMAB-C3623-YY)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYY-C2185

Application*: WB

Mouse Anti-CSNK1G2 Recombinant Antibody (CBYY-C2184) (CBMAB-C3622-YY)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C2184

Application*: WB, IP, IF, E

Mouse Anti-CSNK1G2 Recombinant Antibody (1A9) (CBMAB-C3601-LY)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 1A9

Application*: WB

Human Recombinant CSNK1G2 protein, His Tag (V2LY-0526-LY2593)

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Target: CSNK1G2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 18-415

Tag: His Tag

Human Recombinant CSNK1G2, Active protein, GST Tag (V2LY-0526-LY2592)

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Target: CSNK1G2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Mouse Anti-CSNK1G2 Recombinant Antibody (2E6) (V2LY-0125-LY40)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E6

Application*: WB, E

Mouse Anti-CSNK1G2 Recombinant Antibody (CBXC-2112) (V2LY-0125-LY39)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBXC-2112

Application*: WB

Mouse Anti-CSNK1G2 Recombinant Antibody (CBFYC-2301) (V2LY-0125-LY36)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-2301

Application*: WB, IP

Mouse Anti-CSNK1G2 Recombinant Antibody (CBFYC-2300) (V2LY-0125-LY35)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-2300

Application*: E, WB

Mouse Anti-CSNK1G2 Recombinant Antibody (4H3) (V2LY-0125-LY34)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4H3

Application*: IH, WB

Mouse Anti-CSNK1G2 Recombinant Antibody (3G4) (V2LY-0125-LY33)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 3G4

Application*: WB

Mouse Anti-CSNK1G2 Recombinant Antibody (3F4) (V2LY-0125-LY32)

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Target: CSNK1G2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F4

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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