CSNK1G2

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are FoxO family signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.
Full Name
casein kinase 1, gamma 2
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Biological Process
Endocytosis Source: GO_Central
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: Reactome
Wnt signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Cell cortex
PTM
Autophosphorylated (PubMed:18794808). Phosphorylated by aPKC which promotes dissociation from the cell cortex (PubMed:26481050).
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Anti-CSNK1G2 antibodies

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Mouse Anti-CSNK1G2 Recombinant Antibody (CBYY-C2185) (CBMAB-C3623-YY)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYY-C2185
Application*: WB
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (CBYY-C2184) (CBMAB-C3622-YY)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2184
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (1A9) (CBMAB-C3601-LY)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1A9
Application*: WB
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (2E6) (V2LY-0125-LY40)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E6
Application*: WB, E
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (CBXC-2112) (V2LY-0125-LY39)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXC-2112
Application*: WB
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (CBFYC-2301) (V2LY-0125-LY36)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2301
Application*: WB, IP
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (CBFYC-2300) (V2LY-0125-LY35)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2300
Application*: E, WB
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (4H3) (V2LY-0125-LY34)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4H3
Application*: IH, WB
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (3G4) (V2LY-0125-LY33)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 3G4
Application*: WB
Datasheet SDS

Mouse Anti-CSNK1G2 Recombinant Antibody (3F4) (V2LY-0125-LY32)

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Target: CSNK1G2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F4
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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