CSNK1G2

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are FoxO family signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.

casein kinase 1, gamma 2

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Endocytosis Source: GO_Central
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: Reactome
Wnt signaling pathway Source: GO_Central

Cytoplasm; Cell cortex

Autophosphorylated (PubMed:18794808). Phosphorylated by aPKC which promotes dissociation from the cell cortex (PubMed:26481050).