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CSTA

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.

Full Name

CSTA

Function

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.

Biological Process

Cell-cell adhesion Source: UniProtKB
Cornification Source: Reactome
Keratinocyte differentiation Source: UniProtKB
Negative regulation of peptidase activity Source: BHF-UCL
Negative regulation of proteolysis Source: UniProtKB
Peptide cross-linking Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Peeling skin syndrome 4 (PSS4):
A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.

Anti-CSTA antibodies

Mouse Anti-CSTA Antibody (5BA10) (CBMAB-1099CQ)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5BA10

Application*: E, WB

Mouse Anti-CSTA Antibody (5BA9) (CBMAB-1098CQ)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5BA9

Application*: E, WB

Mouse Anti-CSTA Recombinant Antibody (CBWJC-3274) (CBMAB-C4472WJ)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3274

Application*: C, WB

Rat Anti-CSTA Recombinant Antibody (CBXC-1501) (CBMAB-C5930-CQ)

SDS

Target: CSTA

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXC-1501

Application*: N, WB

Mouse Anti-CSTA Recombinant Antibody (CBFYC-2349) (CBMAB-C2421-FY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBFYC-2349

Application*: WB

Mouse Anti-CSTA Recombinant Antibody (CBFYC-2350) (CBMAB-C2422-FY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-2350

Application*: IH, WB

Mouse Anti-CSTA Recombinant Antibody (CBFYC-2351) (CBMAB-C2423-FY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-2351

Application*: WB, IP

Mouse Anti-CSTA (AA 1-98) Recombinant Antibody (CBFYC-2352) (CBMAB-C2424-FY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-2352

Application*: E, WB

Mouse Anti-CSTA (AA 1-98) Recombinant Antibody (CBFYC-2353) (CBMAB-C2425-FY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-2353

Application*: WB, F, E, IF

Mouse Anti-CSTA Recombinant Antibody (CBFYC-2354) (CBMAB-C2426-FY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2354

Application*: P

Rabbit Anti-CSTA Recombinant Antibody (CBFYC-2355) (CBMAB-C2427-FY)

SDS

Target: CSTA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-2355

Application*: WB, IP

Mouse Anti-CSTA Recombinant Antibody (CBXC-1919) (CBMAB-C3827-CQ)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-1919

Application*: WB, F, E, IF

Mouse Anti-CSTA Recombinant Antibody (BV23/2) (CBMAB-C3015-CN)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BV23/2

Application*: IH, WB

Mouse Anti-CSTA Recombinant Antibody (WR-23/2/3/3) (CBMAB-C3016-CN)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: WR-23/2/3/3

Application*: IH, P

Mouse Anti-CSTA Recombinant Antibody (CBCNC-432) (CBMAB-C3017-CN)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-432

Application*: IH, WB

Mouse Anti-CSTA Recombinant Antibody (CBCNC-434) (CBMAB-C3019-CN)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-434

Application*: WB, ICC, P, E

Mouse Anti-CSTA Recombinant Antibody (MM0227-2D26) (CBMAB-C11264-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0227-2D26

Application*: WB

Mouse Anti-CSTA Recombinant Antibody (CBXC-1607) (CBMAB-C3826-CQ)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXC-1607

Application*: E, WB

Mouse Anti-CSTA Recombinant Antibody (224705) (CBMAB-C0678-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 224705

Application*: WB, IP

Rat Anti-CSTA Recombinant Antibody (263423) (CBMAB-C0761-LY)

SDS

Target: CSTA

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 263423

Application*: WB, IP

Mouse Anti-CSTA Recombinant Antibody (01) (CBMAB-C1582-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 01

Application*: P

Mouse Anti-CSTA Recombinant Antibody (13A249) (CBMAB-C2750-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 13A249

Application*: C, WB

Mouse Anti-CSTA Recombinant Antibody (14L335) (CBMAB-C3173-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L335

Application*: WB

Mouse Anti-CSTA Recombinant Antibody (1A11) (CBMAB-C3511-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A11

Application*: E, WB

Mouse Anti-CSTA Recombinant Antibody (1B12) (CBMAB-C3623-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1B12

Application*: WB, F, E, IC/IF

Rabbit Anti-CSTA Recombinant Antibody (236) (CBMAB-C4445-LY)

SDS

Target: CSTA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 236

Application*: WB, IP

Mouse Anti-CSTA Recombinant Antibody (2D26) (CBMAB-C4880-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 2D26

Application*: WB

Mouse Anti-CSTA Recombinant Antibody (4D8) (CBMAB-C6812-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4D8

Application*: E, WB

Mouse Anti-CSTA Recombinant Antibody (6D331) (CBMAB-C8205-LY)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D331

Application*: C, WB

Mouse Anti-CSTA Recombinant Antibody (CBCNC-091) (CBMAB-C0986-CN)

SDS

Target: CSTA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-091

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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