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Mouse Anti-CSTA Recombinant Antibody (01) (CBMAB-C1582-LY)

This product is antibody recognizes CSTA. The antibody 01 immunoassay techniques such as: IHC-P.
See all CSTA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
01
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Recombinant Human Cystatin A / CSTA protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CSTA
Introduction
CSTA (Cystatin A) is a Protein Coding gene. Diseases associated with CSTA include Peeling Skin Syndrome 4 and Peeling Skin Syndrome 2. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is CSTB.
Entrez Gene ID
1475
UniProt ID
P01040
Alternative Names
Cystatin A; Cystatin A (Stefin A); STF1; STFA; Cystatin AS; Cystatin-AS;
Function
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
Biological Process
Cell-cell adhesion Source: UniProtKB
Cornification Source: Reactome
Keratinocyte differentiation Source: UniProtKB
Negative regulation of peptidase activity Source: BHF-UCL
Negative regulation of proteolysis Source: UniProtKB
Peptide cross-linking Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Peeling skin syndrome 4 (PSS4):
A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.

Mary, D. J. S. J., Sikarwar, G., Kumar, A., & Limaye, A. M. (2020). Interplay of ERα binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells. Molecular and Cellular Endocrinology, 504, 110701.

Mezzapesa, A., Bastelica, D., Crescence, L., Poggi, M., Grino, M., Peiretti, F., ... & Canault, M. (2019). Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis. Scientific reports, 9(1), 1-15.

Dohm, A., Su, J., McTyre, E. R., Taylor, J. M., Miller, L. D., Petty, W. J., ... & Ruiz, J. (2019). Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: Analysis of a prospective trial. The International journal of biological markers, 34(1), 90-97.

Ma, Y., Chen, Y., Li, Y., Grün, K., Berndt, A., Zhou, Z., & Petersen, I. (2018). Cystatin A suppresses tumor cell growth through inhibiting epithelial to mesenchymal transition in human lung cancer. Oncotarget, 9(18), 14084.

Shiba, D., Terayama, M., Yamada, K., Hagiwara, T., Oyama, C., Tamura-Nakano, M., ... & Kawamura, Y. I. (2018). Clinicopathological significance of cystatin A expression in progression of esophageal squamous cell carcinoma. Medicine, 97(15).

Komura, T., Takabatake, H., Harada, K., Yamato, M., Miyazawa, M., Yoshida, K., ... & Sakai, Y. (2017). Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. Cancer science, 108(11), 2122-2129.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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