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CXCL11

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq]
Full Name
chemokine (C-X-C motif) ligand 11
Function
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
T cell chemotaxis Source: UniProtKB
Cellular Location
Secreted

Anti-CXCL11 antibodies

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Target: CXCL11
Host: Mouse
Specificity: Rat
Clone: CBCNC-516
Application*: WB, ICC, P, IH-F, E
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJC-3478
Application*: N, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2317
Application*: WB, N
Target: CXCL11
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1492
Application*: N, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1341
Application*: WB, N, EC
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2347
Application*: WB, E
Target: CXCL11
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2498
Application*: WB, N
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-2497
Application*: N, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0452
Application*: WB, SE
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0196
Application*: WB, E
Target: CXCL11
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0203-17L2
Application*: WB, B/N
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0210-9N26
Application*: WB, N
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C6
Application*: E, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2348
Application*: E(Det), N, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2347
Application*: E
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 87328
Application*: ED, N, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D9
Application*: E
Target: CXCL11
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 17L2
Application*: WB, N
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L306
Application*: N, WB
Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 22F1
Application*: WB, E
Target: CXCL11
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 131327
Application*: WB, N
Target: CXCL11
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR11076
Application*: IF, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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