CXCL11

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq]
Full Name
chemokine (C-X-C motif) ligand 11
Function
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
T cell chemotaxis Source: UniProtKB
Cellular Location
Secreted
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Anti-CXCL11 antibodies

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Mouse Anti-CXCL11 Recombinant Antibody (C11356) (V2LY-0125-LY642)

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Target: CXCL11
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: C11356
Application*: WB, N
Functional Assay
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBXC-2317) (V2LY-0125-LY641)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2317
Application*: E, WB
Datasheet SDS

Rat Anti-CXCL11 Recombinant Antibody (CBXC-1492) (V2LY-0125-LY640)

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Target: CXCL11
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1492
Application*: N, WB, E, IH
Functional Assay
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBXC-2347) (V2LY-0125-LY639)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2347
Application*: WB, P, F, E, N
Functional Assay
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBYY-C2348) (V2LY-0125-LY638)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2348
Application*: E
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBYY-C2347) (V2LY-0125-LY637)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2347
Application*: P
Datasheet SDS

Rat Anti-CXCL11 Recombinant Antibody (CBFYC-2498) (V2LY-0125-LY636)

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Target: CXCL11
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2498
Application*: E, WB
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBFYC-2497) (V2LY-0125-LY635)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2497
Application*: E
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBFYC-0452) (V2LY-0125-LY634)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBFYC-0452
Application*: E
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (CBFYC-0196) (V2LY-0125-LY633)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0196
Application*: E
Datasheet SDS

Mouse Anti-CXCL11 Recombinant Antibody (3D9) (V2LY-0125-LY632)

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Target: CXCL11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D9
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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