Human Recombinant CXCL11 protein (V2LY-0526-LY3433)

Name: Human Recombinant CXCL11 protein
SKU: V2LY-0526-LY3433
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant CXCL11 protein consist of Amino Acid: 22-94 and predicts a molecular mass of 8.3 kDa.

Molecule Mass

8.3 kDa

Sequence

Amino Acid: 22-94

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chemokine (C-X-C motif) ligand 11

Function

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
T cell chemotaxis Source: UniProtKB

Cellular Location

Secreted

Cao, Y., Jiao, N., Sun, T., Ma, Y., Zhang, X., Chen, H., ... & Zhang, Y. (2021). CXCL11 correlates with antitumor immunity and an improved prognosis in colon cancer. Frontiers in cell and developmental biology, 9.

Kumaravel, S., Singh, S., Roy, S., Venkatasamy, L., White, T. K., Sinha, S., ... & Chakraborty, S. (2020). CXCL11-CXCR3 axis mediates tumor lymphatic cross talk and inflammation-induced tumor, promoting pathways in head and neck cancers. The American journal of pathology, 190(4), 900-915.

Kameda, M., Otsuka, M., Chiba, H., Kuronuma, K., Hasegawa, T., Takahashi, H., & Takahashi, H. (2020). CXCL9, CXCL10, and CXCL11; biomarkers of pulmonary inflammation associated with autoimmunity in patients with collagen vascular diseases–associated interstitial lung disease and interstitial pneumonia with autoimmune features. PloS one, 15(11), e0241719.

Zhang, Y., Zhao, W., Li, S., Lv, M., Yang, X., Li, M., & Zhang, Z. (2019). CXCL11 promotes self-renewal and tumorigenicity of α2δ1+ liver tumor-initiating cells through CXCR3/ERK1/2 signaling. Cancer letters, 449, 163-171.

Han, B., Feng, D., Yu, X., Liu, Y., Yang, M., Luo, F., ... & Liu, F. (2018). MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11. Experimental and therapeutic medicine, 16(3), 1935-1943.

Tokunaga, R., Zhang, W. U., Naseem, M., Puccini, A., Berger, M. D., Soni, S., ... & Lenz, H. J. (2018). CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation–a target for novel cancer therapy. Cancer treatment reviews, 63, 40-47.

Han, J., Gu, M. J., Yoo, I., Choi, Y., Jang, H., Kim, M., ... & Ka, H. (2017). Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal–conceptus interface in pigs. Biology of reproduction, 97(1), 69-80.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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