CXCL3

CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL2.

Full Name

C-X-C Motif Chemokine Ligand 3

Function

Ligand for CXCR2 (By similarity).

Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB

Cellular Location

Secreted

PTM

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Anti-CXCL3 antibodies

Mouse Anti-CXCL3 Recombinant Antibody (CBCNC-524) (CBMAB-C3221-CN)

Datasheet

SDS

Target: CXCL3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-524

Application*: E, WB

Mouse Anti-CXCL3 Recombinant Antibody (CBFYC-2517) (CBMAB-C2591-FY)

Datasheet

SDS

Target: CXCL3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2517

Application*: E

Mouse Anti-CXCL3 Recombinant Antibody (CBYY-C2351) (CBMAB-C3789-YY)

Datasheet

SDS

Target: CXCL3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: CBYY-C2351

Application*: WB, N, E(Cap)

Mouse Anti-CXCL3 Recombinant Antibody (83504) (CBMAB-C8967-LY)

Datasheet

SDS

Target: CXCL3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: 83504

Application*: WB, N, EC

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)