CXCL3

CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL2.

Full Name

C-X-C Motif Chemokine Ligand 3

Function

Ligand for CXCR2 (By similarity).

Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB

Cellular Location

Secreted

PTM

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.