Rat Cxcl3 ELISA Kit (V2LY-0626-LY1940)

Name: Rat Cxcl3 ELISA Kit
SKU: V2LY-0626-LY1940
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0052 ng/mL

Detection Range

0.01-2 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Molecule Mass

11.1 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 3

Function

Ligand for CXCR2 (By similarity).

Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB

Cellular Location

Secreted

PTM

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Reyes, N., Figueroa, S., Tiwari, R., & Geliebter, J. (2021). CXCL3 Signaling in the Tumor Microenvironment. Tumor Microenvironment, 15-24.

Lv, Q. Y., Zou, H. Z., Xu, Y. Y., Shao, Z. Y., Wu, R. Q., Li, K. J., ... & Zou, C. L. (2021). Expression levels of chemokine (CXC motif) ligands CXCL1 and CXCL3 as prognostic biomarkers in rectal adenocarcinoma: evidence from Gene Expression Omnibus (GEO) analyses. Bioengineered, 12(1), 3711-3725.

Aguilera-Durán, G., & Romo-Mancillas, A. (2020). Computational study of CXC chemokine receptor (CXCR) 3 binding with its natural agonists chemokine (CXC Motif) ligand (CXCL) 9, 10 and 11 and with synthetic antagonists: Insights of receptor activation towards drug design for vitiligo. Molecules, 25(19), 4413.

Ruan, G. T., Gong, Y. Z., Liao, X. W., Wang, S., Huang, W., Wang, X. K., ... & Gao, F. (2019). Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. Oncology reports, 42(5), 1996-2008.

Kuo, P. T., Zeng, Z., Salim, N., Mattarollo, S., Wells, J. W., & Leggatt, G. R. (2018). The role of CXCR3 and its chemokine ligands in skin disease and cancer. Frontiers in Medicine, 271.

Metzemaekers, M., Vanheule, V., Janssens, R., Struyf, S., & Proost, P. (2018). Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands. Frontiers in immunology, 8, 1970.

Liu, Q. Z., Ma, W. T., Yang, J. B., Zhao, Z. B., Yan, K., Yao, Y., ... & Lian, Z. X. (2018). The CXC chemokine receptor 3 inhibits autoimmune cholangitis via CD8+ T cells but promotes colitis via CD4+ T cells. Frontiers in immunology, 9, 1090.

Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., ... & Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13(6), 4224-4230.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Cxcl3 ELISA Kit (CAT#: V2LY-0626-LY2249)

Human CXCL3 ELISA Kit (CAT#: V2LY-0626-LY4458)

Human Recombinant CXCL3 protein, His Tag (CAT#: V2LY-0526-LY4424)

Mouse Recombinant CXCL3 protein, His Tag (CAT#: V2LY-0526-LY8376)

Related Products

Mouse Recombinant CXCL3 protein, His Tag (CAT#: V2LY-0526-LY8376)

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Mouse Anti-CXCL3 Recombinant Antibody (CBFYC-2517) (CAT#: CBMAB-C2591-FY)

Human CXCL3 ELISA Kit (CAT#: V2LY-0626-LY4458)

Mouse Cxcl3 ELISA Kit (CAT#: V2LY-0626-LY2249)

Human Recombinant CXCL3 protein, His Tag (CAT#: V2LY-0526-LY4424)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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