Mouse Anti-CXCL3 Recombinant Antibody (CBYY-C2351) (V2LY-0125-LY703)

Name: Mouse Anti-CXCL3 Recombinant Antibody (CBYY-C2351)
SKU: V2LY-0125-LY703
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C2351

Application

ELISA

Immunogen

Recombinant Human CXCL3 / GRO gamma Protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 3

Entrez Gene ID

171551

UniProt ID

Q10746

Function

Ligand for CXCR2 (By similarity).

Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB

Cellular Location

Secreted

PTM

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Reyes, N., Figueroa, S., Tiwari, R., & Geliebter, J. (2021). CXCL3 Signaling in the Tumor Microenvironment. Tumor Microenvironment, 15-24.

Lv, Q. Y., Zou, H. Z., Xu, Y. Y., Shao, Z. Y., Wu, R. Q., Li, K. J., ... & Zou, C. L. (2021). Expression levels of chemokine (CXC motif) ligands CXCL1 and CXCL3 as prognostic biomarkers in rectal adenocarcinoma: evidence from Gene Expression Omnibus (GEO) analyses. Bioengineered, 12(1), 3711-3725.

Aguilera-Durán, G., & Romo-Mancillas, A. (2020). Computational study of CXC chemokine receptor (CXCR) 3 binding with its natural agonists chemokine (CXC Motif) ligand (CXCL) 9, 10 and 11 and with synthetic antagonists: Insights of receptor activation towards drug design for vitiligo. Molecules, 25(19), 4413.

Ruan, G. T., Gong, Y. Z., Liao, X. W., Wang, S., Huang, W., Wang, X. K., ... & Gao, F. (2019). Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. Oncology reports, 42(5), 1996-2008.

Kuo, P. T., Zeng, Z., Salim, N., Mattarollo, S., Wells, J. W., & Leggatt, G. R. (2018). The role of CXCR3 and its chemokine ligands in skin disease and cancer. Frontiers in Medicine, 271.

Metzemaekers, M., Vanheule, V., Janssens, R., Struyf, S., & Proost, P. (2018). Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands. Frontiers in immunology, 8, 1970.

Liu, Q. Z., Ma, W. T., Yang, J. B., Zhao, Z. B., Yan, K., Yao, Y., ... & Lian, Z. X. (2018). The CXC chemokine receptor 3 inhibits autoimmune cholangitis via CD8+ T cells but promotes colitis via CD4+ T cells. Frontiers in immunology, 9, 1090.

Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., ... & Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13(6), 4224-4230.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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