CXCL6

CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include Mastitis and Rheumatoid Arthritis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is CXCL5.

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Leukocyte homeostasis Source: Ensembl
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of chemokine production Source: Ensembl
Regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
Signal transduction Source: ProtInc

Secreted