CXCL6
CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include Mastitis and Rheumatoid Arthritis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is CXCL5.
Full Name
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Function
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Leukocyte homeostasis Source: Ensembl
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of chemokine production Source: Ensembl
Regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
Signal transduction Source: ProtInc
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Leukocyte homeostasis Source: Ensembl
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of chemokine production Source: Ensembl
Regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
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Anti-CXCL6 antibodies
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CompareTarget: CXCL6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1261
Application*: E
Target: CXCL6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2357
Application*: E
Target: CXCL6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2521
Application*: WB, N, E, P
Target: CXCL6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2520
Application*: WB, N
Target: CXCL6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C7867
Application*: WB, IF
Target: CXCL6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G1501
Application*: E
Target: CXCL6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G3
Application*: E
Target: CXCL6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G12
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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