Human CXCL6 ELISA Kit (V2LY-0626-LY515)

Name: Human CXCL6 ELISA Kit
SKU: V2LY-0626-LY515
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.022 ng/mL

Detection Range

0.05-10 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

11.9 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

Function

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Leukocyte homeostasis Source: Ensembl
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of chemokine production Source: Ensembl
Regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

Jiang, Y., Xi, Y., Li, Y., Zuo, Z., Zeng, C., Fan, J., ... & Guo, Y. (2022). Ethanol promoting the upregulation of CXC Motif Chemokine Ligand 1（ CXCL1） and CXC Motif Chemokine Ligand 6（ CXCL6） in models of early alcoholic liver disease. Bioengineered, 13(3), 4688-4701.

Wang, S. Z., Zhang, Y. L., & Shi, H. B. (2021). Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting CXC Motif Chemokine Ligand 6. Archives of Medical Research, 52(1), 58-68.

Wang, X., Dai, Y., Zhang, X., Pan, K., Deng, Y., Wang, J., & Xu, T. (2021). CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia–reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. Cancer Biology & Therapy, 22(1), 30-39.

Zheng, S., Shen, T., Liu, Q., Liu, T., Tuerxun, A., Zhang, Q., ... & Lu, X. (2021). CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD‐L1 via activation of STAT3 pathway. Journal of Cellular Physiology, 236(7), 5373-5386.

Sun, C., Li, G., & Liu, M. (2020). A novel circular RNA, circ_0005394, predicts unfavorable prognosis and contributes to hepatocellular carcinoma progression by regulating miR-507/E2F3 and miR-515-5p/CXCL6 signaling pathways. OncoTargets and therapy, 13, 6171.

Liu, G., An, L., Zhang, H., Du, P., & Sheng, Y. (2019). Activation of CXCL6/CXCR1/2 axis promotes the growth and metastasis of osteosarcoma cells in vitro and in vivo. Frontiers in pharmacology, 10, 307.

Yamamoto, Y., Kuroda, K., Sera, T., Sugimoto, A., Kushiyama, S., Nishimura, S., ... & Yashiro, M. (2019). The clinicopathological significance of the CXCR2 ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in gastric cancer. Anticancer research, 39(12), 6645-6652.

Shen, W., Xie, X. Y., Liu, M. R., & Wang, L. L. (2019). MicroRNA-101-5p inhibits the growth and metastasis of cervical cancer cell by inhibiting CXCL6. Eur Rev Med Pharmacol Sci, 23(5), 1957-1968.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cattle CXCL6 ELISA Kit (CAT#: V2LY-0626-LY2506)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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