DDIT4

DDIT4 (DNA Damage Inducible Transcript 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include 14-3-3 protein binding. An important paralog of this gene is DDIT4L.

Full Name

DNA Damage Inducible Transcript 4

Function

Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity).

Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).

Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Biological Process

Apoptotic process Source: GO_Central
Brain development Source: UniProtKB
Cellular response to dexamethasone stimulus Source: Ensembl
Defense response to virus Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
Negative regulation of glycolytic process Source: Ensembl
Negative regulation of intracellular signal transduction Source: UniProtKB
Negative regulation of peptidyl-serine phosphorylation Source: UniProtKB
Negative regulation of peptidyl-threonine phosphorylation Source: UniProtKB
Negative regulation of TOR signaling Source: UniProtKB
Neuron differentiation Source: UniProtKB
Neuron migration Source: UniProtKB
Neurotrophin TRK receptor signaling pathway Source: UniProtKB
Positive regulation of neuron death Source: UniProtKB
Protein-containing complex disassembly Source: Ensembl
Reactive oxygen species metabolic process Source: Ensembl
Regulation of TOR signaling Source: GO_Central
Response to hypoxia Source: UniProtKB

Cellular Location

Cytosol; Mitochondrion

PTM

Phosphorylated by GSK3B; this promotes proteasomal degradation.
Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation.