DLG5

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq]

discs, large homolog 5 (Drosophila)

Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360).

Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714).

Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360).

Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Apical protein localization Source: Ensembl
Cell-cell adhesion Source: UniProtKB
Epithelial to mesenchymal transition Source: UniProtKB
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
Intracellular signal transduction Source: UniProtKB
Maintenance of cell polarity Source: UniProtKB
Metanephric collecting duct development Source: Ensembl
Midbrain development Source: Ensembl
Negative regulation of cell migration Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of hippo signaling Source: UniProtKB
Negative regulation of T cell proliferation Source: UniProtKB
Polarized epithelial cell differentiation Source: Ensembl
Positive regulation of dendritic spine development Source: UniProtKB
Positive regulation of hippo signaling Source: UniProtKB
Positive regulation of smoothened signaling pathway Source: UniProtKB
Positive regulation of synapse assembly Source: UniProtKB
Protein-containing complex assembly Source: Ensembl
Protein localization to adherens junction Source: Ensembl
Regulation of apoptotic process Source: InterPro
Signal transduction Source: ProtInc
Zonula adherens assembly Source: Ensembl

Cell membrane; Cilium basal body; Cell junction; Postsynaptic density. Localized at sites of cell-cell contact.