DPP8

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
Full Name
dipeptidyl-peptidase 8
Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable).

Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818).
Biological Process
Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
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Anti-DPP8 antibodies

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Human DPP8 ELISA Kit (V2LY-0626-LY2475)

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Target: DPP8
Sensitivity: 0.025 ng/mL
Detection Range: 0.05-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-DPP8 Recombinant Antibody (1B10) (V2LY-0425-LY866)

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Target: DPP8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B10
Application*: E
Datasheet SDS

Mouse Anti-DPP8 Recombinant Antibody (CBYCD-393) (V2LY-0425-LY865)

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Target: DPP8
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-393
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DPP8 Recombinant Antibody (1B10) (CBMAB-D1610-YC)

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Target: DPP8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B10
Application*: E
Datasheet SDS

Mouse Anti-DPP8 Recombinant Antibody (CBYCD-393) (CBMAB-D1608-YC)

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Target: DPP8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-393
Application*: WB, IC, P, C, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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