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Mouse Anti-DPP8 Recombinant Antibody (CBYCD-393) (V2LY-0425-LY865)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYCD-393
Antibody Isotype
IgM, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 11-80 mapping near the N-terminus of human DPRP1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dipeptidyl-peptidase 8
Entrez Gene ID
54878
UniProt ID
Q6V1X1
Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable).

Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818).
Biological Process
Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
More Infomation

Liu, H. F., Xie, Y. K., Zhong, B. Y., Zhang, J. H., Song, C. X., Liu, Y. W., ... & Xie, B. H. (2022). Dipeptidyl peptidase‐8 induces sorafenib resistance via binding with c‐Rel to mediate NF‐κB signaling in hepatocellular carcinoma. Cell Biology International, 46(2), 213-221.

Suski, M., Wiśniewska, A., Kuś, K., Kiepura, A., Stachowicz, A., Stachyra, K., ... & Olszanecki, R. (2020). Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages–quantitative proteomics of the proteome and secretome. Molecular Immunology, 127, 193-202.

Johnson, D. C., Okondo, M. C., Orth, E. L., Rao, S. D., Huang, H. C., Ball, D. P., & Bachovchin, D. A. (2020). DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell death & disease, 11(8), 1-10.

Brunetti, M., Holth, A., Panagopoulos, I., Staff, A. C., Micci, F., & Davidson, B. (2019). Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma. Virchows Archiv, 474(2), 177-185.

Ross, B., Krapp, S., Augustin, M., Kierfersauer, R., Arciniega, M., Geiss-Friedlander, R., & Huber, R. (2018). Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proceedings of the National Academy of Sciences, 115(7), E1437-E1445.

Chen, Y., Liu, F., Wu, K., Wu, W., Wu, H., & Zhang, W. (2018). Targeting dipeptidyl peptidase 8 genes inhibits proliferation, migration and invasion by inhibition of cyclin D1 and MMP2MMP9 signal pathway in cervical cancer. The Journal of Gene Medicine, 20(12), e3056.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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