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Mouse Anti-DPP8 Recombinant Antibody (1B10) (CBMAB-D1610-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dipeptidyl Peptidase 8 (DPP8). The antibody can be used for immunoassay techniques, such as ELISA.
See all DPP8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
DPP8 (NP_932065.1, 161 a.a. ~ 244 a.a) partial recombinant protein with GST tag. The immunogen sequence: IGTVGIASYD YHQGSGTFLF QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN IVTR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 161-244

Target

Full Name
dipeptidyl-peptidase 8
Introduction
DPP8 belongs to the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function.
Entrez Gene ID
54878
UniProt ID
Q6V1X1
Alternative Names
Dipeptidyl Peptidase 8; Dipeptidyl Peptidase VIII; Prolyl Dipeptidase DPP8; Dipeptidyl Peptidase IV-Related Protein 1; DPP VIII; DPRP-1; DPRP1; DP8; Dipeptidyl Peptidase IV-Related Protein-1;
Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable).

Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818).
Biological Process
Apoptotic process Source: UniProtKB-KW
Immune response Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm

Liu, H. F., Xie, Y. K., Zhong, B. Y., Zhang, J. H., Song, C. X., Liu, Y. W., ... & Xie, B. H. (2022). Dipeptidyl peptidase‐8 induces sorafenib resistance via binding with c‐Rel to mediate NF‐κB signaling in hepatocellular carcinoma. Cell Biology International, 46(2), 213-221.

Suski, M., Wiśniewska, A., Kuś, K., Kiepura, A., Stachowicz, A., Stachyra, K., ... & Olszanecki, R. (2020). Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages–quantitative proteomics of the proteome and secretome. Molecular Immunology, 127, 193-202.

Johnson, D. C., Okondo, M. C., Orth, E. L., Rao, S. D., Huang, H. C., Ball, D. P., & Bachovchin, D. A. (2020). DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell death & disease, 11(8), 1-10.

Brunetti, M., Holth, A., Panagopoulos, I., Staff, A. C., Micci, F., & Davidson, B. (2019). Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma. Virchows Archiv, 474(2), 177-185.

Ross, B., Krapp, S., Augustin, M., Kierfersauer, R., Arciniega, M., Geiss-Friedlander, R., & Huber, R. (2018). Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proceedings of the National Academy of Sciences, 115(7), E1437-E1445.

Chen, Y., Liu, F., Wu, K., Wu, W., Wu, H., & Zhang, W. (2018). Targeting dipeptidyl peptidase 8 genes inhibits proliferation, migration and invasion by inhibition of cyclin D1 and MMP2MMP9 signal pathway in cervical cancer. The Journal of Gene Medicine, 20(12), e3056.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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