ECM1
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Full Name
Extracellular Matrix Protein 1
Research Area
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
Biological Process
Angiogenesis Source: UniProtKB-KW
Biomineral tissue development Source: UniProtKB-KW
Chondrocyte development Source: Ensembl
Endochondral bone growth Source: Ensembl
Inflammatory response Source: Ensembl
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of cytokine-mediated signaling pathway Source: Ensembl
Negative regulation of peptidase activity Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of bone mineralization Source: GO_Central
Regulation of T cell migration Source: Ensembl
Regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of type 2 immune response Source: Ensembl
Signal transduction Source: InterPro
Biomineral tissue development Source: UniProtKB-KW
Chondrocyte development Source: Ensembl
Endochondral bone growth Source: Ensembl
Inflammatory response Source: Ensembl
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of cytokine-mediated signaling pathway Source: Ensembl
Negative regulation of peptidase activity Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of bone mineralization Source: GO_Central
Regulation of T cell migration Source: Ensembl
Regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of type 2 immune response Source: Ensembl
Signal transduction Source: InterPro
Cellular Location
Extracellular matrix
Involvement in disease
Lipoid proteinosis (LiP):
Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
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Anti-ECM1 antibodies
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CompareTarget: ECM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-562
Tag: His Tag
Target: ECM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-559
Tag: His Tag
Target: ECM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-540
Tag: His Tag
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 480
Application*: E
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: S6551
Application*: E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1558
Application*: E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: S0427
Application*: E
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0565
Application*: WB, IP, IF, E, P
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0413
Application*: WB, IP, IF, E, P
Target: ECM1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYE-0412
Application*: WB, IP, IF, E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0411
Application*: E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBFYE-0410
Application*: IF, P, WB
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: E0723
Application*: E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: E0044
Application*: E
Target: ECM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 480
Application*: ELISA, IHC, WB
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SC05
Application*: P, IF
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-1558
Application*: WB, IP, P, IF
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NI 194-4
Application*: E, IF, WB
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBYY-I0565
Application*: F, IF, C
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBFYE-0413
Application*: F, E, IH, IF, IP, P, C, EM
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0412
Application*: E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYE-0411
Application*: E
Target: ECM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0410
Application*: E
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SRGP85
Application*: IF, P
Target: ECM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SPM217
Application*: WB, F, E, IF, IP, P, C, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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