Mouse Anti-ECM1 Recombinant Antibody (CBYY-I0565) (CBMAB-I1250-YY)

Name: Mouse Anti-ECM1 Recombinant Antibody (CBYY-I0565)
SKU: CBMAB-I1250-YY
Rating: 5 (1 reviews)

See all ECM1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I0565

Application

FC, IF, IHC-Fr

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.05% BSA, 10mM PBS

Preservative

0.05% azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Extracellular Matrix Protein 1

Introduction

This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

Entrez Gene ID

Human	1893
Rat	116662

UniProt ID

Human	Q16610
Rat	Q62894

Alternative Names

Extracellular Matrix Protein 1; Secretory Component P85; Testicular Tissue Protein Li 61; URBWD;

Research Area

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.

Biological Process

Angiogenesis Source: UniProtKB-KW
Biomineral tissue development Source: UniProtKB-KW
Chondrocyte development Source: Ensembl
Endochondral bone growth Source: Ensembl
Inflammatory response Source: Ensembl
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of cytokine-mediated signaling pathway Source: Ensembl
Negative regulation of peptidase activity Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of bone mineralization Source: GO_Central
Regulation of T cell migration Source: Ensembl
Regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of type 2 immune response Source: Ensembl
Signal transduction Source: InterPro

Cellular Location

Extracellular matrix

Involvement in disease

Lipoid proteinosis (LiP):
Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.

Jeong, S., Lee, S. G., Kim, H., Lee, G., Park, S., Kim, I. K., ... & Jo, Y. S. (2021). Simultaneous Expression of Long Non-Coding RNA FAL1 and Extracellular Matrix Protein 1 Defines Tumour Behaviour in Young Patients with Papillary Thyroid Cancer. Cancers, 13(13), 3223.

Yin, H., Wang, J., Li, H., Yu, Y., Wang, X., Lu, L., ... & Yang, G. (2021). Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nature communications, 12(1), 1-19.

Utsunomiya, N., Utsunomiya, A., Chino, T., Hasegawa, M., & Oyama, N. (2020). Gene silencing of extracellular matrix protein 1 (ECM1) results in phenotypic alterations of dermal fibroblasts reminiscent of clinical features of lichen sclerosus. Journal of Dermatological Science, 100(2), 99-109.

Hardy, S. A., Mabotuwana, N. S., Murtha, L. A., Coulter, B., Sanchez-Bezanilla, S., Al-Omary, M. S., ... & Boyle, A. J. (2019). Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction. PloS one, 14(2), e0212230.

Wang, Z., Zhou, Q., Li, A., Huang, W., Cai, Z., & Chen, W. (2019). Extracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer. OncoTargets and therapy, 12, 1423.

He, L., Gu, W., Wang, M., Chang, X., Sun, X., Zhang, Y., ... & Sun, B. (2018). Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production. Proceedings of the National Academy of Sciences, 115(34), 8621-8626.

Gao, D., Ma, X., Lian, P., Zhou, S., & Chen, J. (2018). Pathogenetic mechanism of lipoid proteinosis caused by mutation of the extracellular matrix protein 1 gene Retraction in/10.3892/mmr. 2019.9925. Molecular Medicine Reports, 17(6), 8087-8090.

Wu, Q., Chen, D., Luo, Q., Yang, Q., Zhao, C., Zhang, D., ... & Qi, Z. (2018). Extracellular matrix protein 1 recruits moesin to facilitate invadopodia formation and breast cancer metastasis. Cancer Letters, 437, 44-55.

Gan, L., Meng, J., Xu, M., Liu, M., Qi, Y., Tan, C., ... & Wang, Z. (2018). Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer. Oncogene, 37(6), 744-755.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-ECM1 Recombinant Antibody (CBYY-I0565)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-ECM1 Recombinant Antibody (CBYY-I0565) (CAT#: V2LY-0425-LY1348)

Related Products

Rabbit Anti-ECM1 Recombinant Antibody (E0044) (CAT#: V2LY-0425-LY1342)

Mouse Anti-ECM1 Recombinant Antibody (NI 194-4) (CAT#: CBMAB-S0427-CQ)

Mouse Anti-ECM1 Recombinant Antibody (480) (CAT#: CBMAB-AP1978LY)

Mouse Anti-ECM1 Recombinant Antibody (SPM217) (CAT#: CBMAB-E0044-FY)

Rabbit Anti-ECM1 Recombinant Antibody (CBFYE-0410) (CAT#: CBMAB-E0724-FY)

Mouse Anti-ECM1 Recombinant Antibody (CBFYE-0413) (CAT#: CBMAB-E0727-FY)

Rabbit Anti-ECM1 Recombinant Antibody (CBFYE-0410) (CAT#: V2LY-0425-LY1344)

Mouse Anti-ECM1 Recombinant Antibody (480) (CAT#: V2LY-0425-LY1352)

Rabbit Anti-ECM1 Recombinant Antibody (CBXS-1558) (CAT#: V2LY-0425-LY1350)

Rabbit Anti-ECM1 Recombinant Antibody (E0723) (CAT#: V2LY-0425-LY1343)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry