Sign in or Register   Sign in or Register
  |  

Mouse Anti-ECM1 Recombinant Antibody (SPM217) (CBMAB-E0044-FY)

This product is mouse antibody that recognizes ECM1. The antibody SPM217 can be used for immunoassay techniques such as: WB, FC, ELISA, IF, IP, IHC-P, IHC-Fr, CyTOF.
See all ECM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
SPM217
Antibody Isotype
IgG1, κ
Application
WB, FC, ELISA, IF, IP, IHC-P, IHC-Fr, CyTOF

Basic Information

Immunogen
Secretory Component protein isolated from human colostrum
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
15 mM Sodium azide, pH 8.0
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Extracellular Matrix Protein 1
Introduction
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
Entrez Gene ID
Human1893
Rat116662
UniProt ID
HumanQ16610
RatQ62894
Alternative Names
Extracellular Matrix Protein 1; Secretory Component P85; Testicular Tissue Protein Li 61; URBWD
Research Area
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
Biological Process
Angiogenesis Source: UniProtKB-KW
Biomineral tissue development Source: UniProtKB-KW
Chondrocyte development Source: Ensembl
Endochondral bone growth Source: Ensembl
Inflammatory response Source: Ensembl
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of cytokine-mediated signaling pathway Source: Ensembl
Negative regulation of peptidase activity Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of bone mineralization Source: GO_Central
Regulation of T cell migration Source: Ensembl
Regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of type 2 immune response Source: Ensembl
Signal transduction Source: InterPro
Cellular Location
Extracellular matrix
Involvement in disease
Lipoid proteinosis (LiP):
Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.

Jeong, S., Lee, S. G., Kim, H., Lee, G., Park, S., Kim, I. K., ... & Jo, Y. S. (2021). Simultaneous Expression of Long Non-Coding RNA FAL1 and Extracellular Matrix Protein 1 Defines Tumour Behaviour in Young Patients with Papillary Thyroid Cancer. Cancers, 13(13), 3223.

Yin, H., Wang, J., Li, H., Yu, Y., Wang, X., Lu, L., ... & Yang, G. (2021). Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nature communications, 12(1), 1-19.

Utsunomiya, N., Utsunomiya, A., Chino, T., Hasegawa, M., & Oyama, N. (2020). Gene silencing of extracellular matrix protein 1 (ECM1) results in phenotypic alterations of dermal fibroblasts reminiscent of clinical features of lichen sclerosus. Journal of Dermatological Science, 100(2), 99-109.

Hardy, S. A., Mabotuwana, N. S., Murtha, L. A., Coulter, B., Sanchez-Bezanilla, S., Al-Omary, M. S., ... & Boyle, A. J. (2019). Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction. PloS one, 14(2), e0212230.

Wang, Z., Zhou, Q., Li, A., Huang, W., Cai, Z., & Chen, W. (2019). Extracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer. OncoTargets and therapy, 12, 1423.

He, L., Gu, W., Wang, M., Chang, X., Sun, X., Zhang, Y., ... & Sun, B. (2018). Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production. Proceedings of the National Academy of Sciences, 115(34), 8621-8626.

Gao, D., Ma, X., Lian, P., Zhou, S., & Chen, J. (2018). Pathogenetic mechanism of lipoid proteinosis caused by mutation of the extracellular matrix protein 1 gene Retraction in/10.3892/mmr. 2019.9925. Molecular Medicine Reports, 17(6), 8087-8090.

Wu, Q., Chen, D., Luo, Q., Yang, Q., Zhao, C., Zhang, D., ... & Qi, Z. (2018). Extracellular matrix protein 1 recruits moesin to facilitate invadopodia formation and breast cancer metastasis. Cancer Letters, 437, 44-55.

Gan, L., Meng, J., Xu, M., Liu, M., Qi, Y., Tan, C., ... & Wang, Z. (2018). Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer. Oncogene, 37(6), 744-755.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ECM1 Recombinant Antibody (SPM217)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare