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EDEM1

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L.

Full Name

ER degradation enhancer, mannosidase alpha-like 1

Research Area

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Biological Process

Carbohydrate metabolic process Source: InterPro
Mannose trimming involved in glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Positive regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Protein targeting to ER Source: UniProtKB
Response to unfolded protein Source: UniProtKB-KW
Trimming of terminal mannose on C branch Source: Ensembl
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Ubiquitin-dependent glycoprotein ERAD pathway Source: ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-4
Helical: 5-25
Lumenal: 26-657

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Anti-EDEM1 antibodies

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Mouse Anti-EDEM1 Recombinant Antibody (CBFYE-0025) (V2LY-0425-LY1395)

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Target: EDEM1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0025

Application*: WB, IP, IF, E

Mouse Anti-EDEM1 (AA 559-656) Recombinant Antibody (CBFYE-0025) (CBMAB-E0052-FY)

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Target: EDEM1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYE-0025

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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