EDEM1

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L.

ER degradation enhancer, mannosidase alpha-like 1

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Carbohydrate metabolic process Source: InterPro
Mannose trimming involved in glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
Positive regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Protein targeting to ER Source: UniProtKB
Response to unfolded protein Source: UniProtKB-KW
Trimming of terminal mannose on C branch Source: Ensembl
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Ubiquitin-dependent glycoprotein ERAD pathway Source: ParkinsonsUK-UCL

Endoplasmic reticulum membrane

Cytoplasmic: 1-4
Helical: 5-25
Lumenal: 26-657