EDN2

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. [provided by RefSeq]

Full Name

endothelin 2

Research Area

Endothelins are endothelium-derived vasoconstrictor peptides.

Biological Process

Artery smooth muscle contraction Source: BHF-UCL
Calcium-mediated signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular calcium ion homeostasis Source: GO_Central
Cytokine-mediated signaling pathway Source: BHF-UCL
Energy homeostasis Source: Ensembl
Hormonal regulation of the force of heart contraction Source: BHF-UCL
Inositol phosphate-mediated signaling Source: BHF-UCL
Lung alveolus development Source: Ensembl
Macrophage activation Source: BHF-UCL
Macrophage chemotaxis Source: BHF-UCL
Neutrophil chemotaxis Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of heart rate Source: BHF-UCL
Positive regulation of leukocyte chemotaxis Source: BHF-UCL
Positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
Positive regulation of smooth muscle contraction Source: Ensembl
Positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Prostaglandin biosynthetic process Source: BHF-UCL
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: InterPro
Temperature homeostasis Source: Ensembl
Vasoconstriction Source: BHF-UCL
Vein smooth muscle contraction Source: BHF-UCL

Cellular Location

Secreted