EDN2

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. [provided by RefSeq]
Full Name
endothelin 2
Research Area
Endothelins are endothelium-derived vasoconstrictor peptides.
Biological Process
Artery smooth muscle contraction Source: BHF-UCL
Calcium-mediated signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular calcium ion homeostasis Source: GO_Central
Cytokine-mediated signaling pathway Source: BHF-UCL
Energy homeostasis Source: Ensembl
Hormonal regulation of the force of heart contraction Source: BHF-UCL
Inositol phosphate-mediated signaling Source: BHF-UCL
Lung alveolus development Source: Ensembl
Macrophage activation Source: BHF-UCL
Macrophage chemotaxis Source: BHF-UCL
Neutrophil chemotaxis Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of heart rate Source: BHF-UCL
Positive regulation of leukocyte chemotaxis Source: BHF-UCL
Positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
Positive regulation of smooth muscle contraction Source: Ensembl
Positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Prostaglandin biosynthetic process Source: BHF-UCL
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: InterPro
Temperature homeostasis Source: Ensembl
Vasoconstriction Source: BHF-UCL
Vein smooth muscle contraction Source: BHF-UCL
Cellular Location
Secreted
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Anti-EDN2 antibodies

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Mouse Anti-EDN2 (AA 1-178) Recombinant Antibody (3B4-1C5) (CBMAB-E0767-FY)

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Target: EDN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B4-1C5
Application*: E, WB
Datasheet SDS

Human EDN2 ELISA Kit (V2LY-0626-LY3689)

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Target: EDN2
Sensitivity: 0.0012 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rabbit EDN2 ELISA Kit (V2LY-0626-LY321)

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Target: EDN2
Sensitivity: 0.00043 ng/mL
Detection Range: 0.001-0.3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rabbit
Assay Type: Sandwich
Reactivity: Rabbit
Datasheet SDS

Mouse Edn2 ELISA Kit (V2LY-0626-LY2336)

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Target: Edn2
Sensitivity: 0.00056 ng/mL
Detection Range: 0.001-0.4 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rat Edn2 ELISA Kit (V2LY-0626-LY1321)

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Target: Edn2
Sensitivity: 0.00051 ng/mL
Detection Range: 0.001-0.3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Anti-EDN2 Recombinant Antibody (3B4-1C5) (V2LY-0425-LY1410)

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Target: EDN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B4-1C5
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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