Rabbit EDN2 ELISA Kit (V2LY-0626-LY321)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.00043 ng/mL
Detection Range
0.001-0.3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rabbit
Assay Type
Sandwich
Reactivity
Rabbit
Assay Time
1.5 h
Molecule Mass
19.6 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
endothelin 2
Research Area
Endothelins are endothelium-derived vasoconstrictor peptides.
Biological Process
Artery smooth muscle contraction Source: BHF-UCL
Calcium-mediated signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular calcium ion homeostasis Source: GO_Central
Cytokine-mediated signaling pathway Source: BHF-UCL
Energy homeostasis Source: Ensembl
Hormonal regulation of the force of heart contraction Source: BHF-UCL
Inositol phosphate-mediated signaling Source: BHF-UCL
Lung alveolus development Source: Ensembl
Macrophage activation Source: BHF-UCL
Macrophage chemotaxis Source: BHF-UCL
Neutrophil chemotaxis Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of heart rate Source: BHF-UCL
Positive regulation of leukocyte chemotaxis Source: BHF-UCL
Positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
Positive regulation of smooth muscle contraction Source: Ensembl
Positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Prostaglandin biosynthetic process Source: BHF-UCL
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: InterPro
Temperature homeostasis Source: Ensembl
Vasoconstriction Source: BHF-UCL
Vein smooth muscle contraction Source: BHF-UCL
Cellular Location
Secreted

Eusebi, P. G., Cortés, Ó., Contreras, E., Cañón, J., Dunner, S., & Sevane, N. (2022). A novel missense variant in endothelin‐2 (EDN2) causes a growth and respiratory lethal syndrome in bovine. Animal Genetics.

Ko, C. J., Cho, Y. M., Ham, E., Cacioppo, J. A., & Park, C. J. (2022). Endothelin 2: a key player in ovulation and fertility. Reproduction, 163(4), R71-R80.

Szymanska, M., Shrestha, K., Girsh, E., Harlev, A., Eisenberg, I., Imbar, T., & Meidan, R. (2021). Reduced endothelin-2 and hypoxic signaling pathways in granulosa-lutein cells of PCOS women. International Journal of Molecular Sciences, 22(15), 8216.

Hohos, N. M., Elliott, E. M., Giornazi, A., Silva, E., Rice, J. D., & Skaznik-Wikiel, M. E. (2021). High-fat diet induces an ovulatory defect associated with dysregulated endothelin-2 in mice. Reproduction, 161(3), 307-317.

Szymanska, M., Manthe, S., Shrestha, K., Girsh, E., Harlev, A., Kisliouk, T., & Meidan, R. (2021). Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications. Biology of Reproduction, 104(2), 387-398.

Kobayashi, Y., Watanabe, S., Shirai, M., Yamashiro, C., Ogata, T., Higashijima, F., ... & Kimura, K. (2020). Light-dependent induction of Edn2 expression and attenuation of retinal pathology by endothelin receptor antagonists in Prominin-1-deficient mice. bioRxiv.

Alrashdi, S. F., Deliyanti, D., Talia, D. M., & Wilkinson-Berka, J. L. (2018). Endothelin-2 Injures the Blood–Retinal Barrier and Macroglial Müller Cells: Interactions with Angiotensin II, Aldosterone, and NADPH Oxidase. The American journal of pathology, 188(3), 805-817.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Edn2 ELISA Kit (CAT#: V2LY-0626-LY1321)

Mouse Edn2 ELISA Kit (CAT#: V2LY-0626-LY2336)

Human EDN2 ELISA Kit (CAT#: V2LY-0626-LY3689)

Related Products

Rat Edn2 ELISA Kit (CAT#: V2LY-0626-LY1321)

Mouse Anti-EDN2 (AA 1-178) Recombinant Antibody (3B4-1C5) (CAT#: CBMAB-E0767-FY)

Human EDN2 ELISA Kit (CAT#: V2LY-0626-LY3689)

Mouse Edn2 ELISA Kit (CAT#: V2LY-0626-LY2336)

Mouse Anti-EDN2 Recombinant Antibody (3B4-1C5) (CAT#: V2LY-0425-LY1410)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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