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Mouse Anti-EDN2 (AA 1-178) Recombinant Antibody (3B4-1C5) (CBMAB-E0767-FY)

This product is mouse antibody that recognizes EDN2. The antibody 3B4-1C5 can be used for immunoassay techniques such as: ELISA, WB.
See all EDN2 antibodies
Published Data
Fig. 1 Localization of EDN2 by ISH during the artificial cycle in macaques.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B4-1C5
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-178 from human EDN2 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-178

Target

Full Name
endothelin 2
Introduction
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events.
Entrez Gene ID
1907
UniProt ID
P20800
Alternative Names
ET2; ET-2; PPET2
Research Area
Endothelins are endothelium-derived vasoconstrictor peptides.
Biological Process
Artery smooth muscle contraction Source: BHF-UCL
Calcium-mediated signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular calcium ion homeostasis Source: GO_Central
Cytokine-mediated signaling pathway Source: BHF-UCL
Energy homeostasis Source: Ensembl
Hormonal regulation of the force of heart contraction Source: BHF-UCL
Inositol phosphate-mediated signaling Source: BHF-UCL
Lung alveolus development Source: Ensembl
Macrophage activation Source: BHF-UCL
Macrophage chemotaxis Source: BHF-UCL
Neutrophil chemotaxis Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of heart rate Source: BHF-UCL
Positive regulation of leukocyte chemotaxis Source: BHF-UCL
Positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
Positive regulation of smooth muscle contraction Source: Ensembl
Positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Prostaglandin biosynthetic process Source: BHF-UCL
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: InterPro
Temperature homeostasis Source: Ensembl
Vasoconstriction Source: BHF-UCL
Vein smooth muscle contraction Source: BHF-UCL
Cellular Location
Secreted

Eusebi, P. G., Cortés, Ó., Contreras, E., Cañón, J., Dunner, S., & Sevane, N. (2022). A novel missense variant in endothelin‐2 (EDN2) causes a growth and respiratory lethal syndrome in bovine. Animal Genetics.

Ko, C. J., Cho, Y. M., Ham, E., Cacioppo, J. A., & Park, C. J. (2022). Endothelin 2: a key player in ovulation and fertility. Reproduction, 163(4), R71-R80.

Szymanska, M., Shrestha, K., Girsh, E., Harlev, A., Eisenberg, I., Imbar, T., & Meidan, R. (2021). Reduced endothelin-2 and hypoxic signaling pathways in granulosa-lutein cells of PCOS women. International Journal of Molecular Sciences, 22(15), 8216.

Hohos, N. M., Elliott, E. M., Giornazi, A., Silva, E., Rice, J. D., & Skaznik-Wikiel, M. E. (2021). High-fat diet induces an ovulatory defect associated with dysregulated endothelin-2 in mice. Reproduction, 161(3), 307-317.

Szymanska, M., Manthe, S., Shrestha, K., Girsh, E., Harlev, A., Kisliouk, T., & Meidan, R. (2021). Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications. Biology of Reproduction, 104(2), 387-398.

Kobayashi, Y., Watanabe, S., Shirai, M., Yamashiro, C., Ogata, T., Higashijima, F., ... & Kimura, K. (2020). Light-dependent induction of Edn2 expression and attenuation of retinal pathology by endothelin receptor antagonists in Prominin-1-deficient mice. bioRxiv.

Alrashdi, S. F., Deliyanti, D., Talia, D. M., & Wilkinson-Berka, J. L. (2018). Endothelin-2 Injures the Blood–Retinal Barrier and Macroglial Müller Cells: Interactions with Angiotensin II, Aldosterone, and NADPH Oxidase. The American journal of pathology, 188(3), 805-817.

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For research use only. Not intended for any clinical use.

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