EPHX1

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene

epoxide hydrolase 1, microsomal (xenobiotic)

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity).

Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687).

Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911).

Arachidonic acid metabolic process Source: UniProtKB
Aromatic compound catabolic process Source: UniProtKB-KW
Epoxide metabolic process Source: UniProtKB
Response to organic cyclic compound Source: Ensembl
Response to toxic substance Source: UniProtKB-KW
Xenobiotic metabolic process Source: Reactome

Microsome membrane; Endoplasmic reticulum membrane

In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls.
Familial hypercholanemia (FHCA):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.

Helical: 1-21
Cytoplasmic: 22-455