EPHX1

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene
Full Name
epoxide hydrolase 1, microsomal (xenobiotic)
Research Area
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity).

Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687).

Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911).
Biological Process
Arachidonic acid metabolic process Source: UniProtKB
Aromatic compound catabolic process Source: UniProtKB-KW
Epoxide metabolic process Source: UniProtKB
Response to organic cyclic compound Source: Ensembl
Response to toxic substance Source: UniProtKB-KW
Xenobiotic metabolic process Source: Reactome
Cellular Location
Microsome membrane; Endoplasmic reticulum membrane
Involvement in disease
In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls.
Familial hypercholanemia (FHCA):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Topology
Helical: 1-21
Cytoplasmic: 22-455
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Anti-EPHX1 antibodies

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Mouse Anti-EPHX1 Recombinant Antibody (CBFYE-1037) (CBMAB-E1548-FY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1037
Application*: WB, F
Datasheet SDS

Mouse Anti-EPHX1 Recombinant Antibody (2E7) (CBMAB-A2665-LY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E
Datasheet SDS

Mouse Anti-EPHX1 Recombinant Antibody (CBFYM-1084) (CBMAB-M1239-FY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Dog, Monkey
Clone: CBFYM-1084
Application*: WB, IH
Datasheet SDS

Mouse Anti-EPHX1 Recombinant Antibody (CBFYE-1039) (CBMAB-E1551-FY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYE-1039
Application*: WB, IH
Datasheet SDS

Mouse Anti-EPHX1 Recombinant Antibody (CBFYE-1036) (CBMAB-E1547-FY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-1036
Application*: E
Datasheet SDS

Mouse Anti-EPHX1 Recombinant Antibody (CBFYE-1034) (CBMAB-E1545-FY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-1034
Application*: WB, E, IP
Datasheet SDS

Mouse Anti-EPHX1 Recombinant Antibody (CBFYE-0078) (CBMAB-E0169-FY)

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Target: EPHX1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBFYE-0078
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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