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Mouse Anti-EPHX1 (AA 21-230) Recombinant Antibody (CBFYE-1039) (CBMAB-E1551-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
CBFYE-1039
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 21-230 of human EPHX1 produced in E.coli
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 21-230

Target

Full Name
epoxide hydrolase 1, microsomal (xenobiotic)
Introduction
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
Human2052
Mouse13849
Rat25315
Monkey700180
UniProt ID
HumanP07099
MouseQ9D379
RatP07687
MonkeyA0A5F8AF72
Alternative Names
Epoxide Hydrolase 1; Epoxide Hydrolase 1, Microsomal (Xenobiotic); Epoxide Hydratase; EPHX; EPOX; MEH
Research Area
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity).

Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687).

Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911).
Biological Process
Arachidonic acid metabolic process Source: UniProtKB
Aromatic compound catabolic process Source: UniProtKB-KW
Epoxide metabolic process Source: UniProtKB
Response to organic cyclic compound Source: Ensembl
Response to toxic substance Source: UniProtKB-KW
Xenobiotic metabolic process Source: Reactome
Cellular Location
Microsome membrane; Endoplasmic reticulum membrane
Involvement in disease
In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls.
Familial hypercholanemia (FHCA):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Topology
Helical: 1-21
Cytoplasmic: 22-455
More Infomation

Hasibuan, R. H., Soeroso, N. N., Tarigan, S. P., Siregar, Y., Mutiara, E., & Aktalina, L. (2022). The Relationship of Genetic Polymorphism Micromal Epoxide Hydrolase (EPHX1) His139Arg and Lung Cancer. Jurnal Respirologi Indonesia, 42(2), 86-89.

Hu, T., Zeng, X., Tian, T., & Liu, J. (2021). Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis. Journal of Clinical Neuroscience, 91, 159-171.

Gautheron, J., Morisseau, C., Chung, W. K., Zammouri, J., Auclair, M., Baujat, G., ... & Jeru, I. (2021). EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Elife, 10, e68445.

Demirdöğen, B. C., Miçooğulları, Y., Özçelik, A. T., & Adalı, O. (2020). Missense genetic polymorphisms of microsomal (EPHX1) and soluble epoxide hydrolase (EPHX2) and their relation to the risk of large artery atherosclerotic ischemic stroke in a Turkish population. Neuropsychiatric disease and treatment, 16, 3251.

Long, X., Li, Q., Zhi, L. J., Li, J. M., & Wang, Z. Y. (2020). LINC00205 modulates the expression of EPHX1 through the inhibition of miR‐184 in hepatocellular carcinoma as a ceRNA. Journal of Cellular Physiology, 235(3), 3013-3021.

Wang, Q., Xu, X., Cong, X., Zeng, Z., Xu, L., & Huo, X. (2019). Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma. Environmental geochemistry and health, 41(1), 191-210.

Jin, Y. (2019). Association between EPHX1 polymorphism rs1051740 and the risk of ovarian cancer: a meta-analysis. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 2338-2342.

Edin, M. L., Hamedani, B. G., Gruzdev, A., Graves, J. P., Lih, F. B., Arbes, S. J., ... & Zeldin, D. C. (2018). Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia. Journal of biological chemistry, 293(9), 3281-3292.

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For research use only. Not intended for any clinical use.

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