The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Full Name
exocyst complex component 4
Research Area
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Biological Process
Chemical synaptic transmission Source: GO_Central Exocytosis Source: GO_Central Golgi to plasma membrane transport Source: GO_Central Paraxial mesoderm formation Source: Ensembl Protein transport Source: UniProtKB-KW Regulation of macroautophagy Source: ParkinsonsUK-UCL Vesicle docking involved in exocytosis Source: InterPro Vesicle tethering involved in exocytosis Source: InterPro
Cellular Location
Midbody ring; Cell projection. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes at the leading edge of migrating cells (By similarity).
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