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Mouse Anti-EXOC4 Recombinant Antibody (CBFYE-0282) (CBMAB-E0562-FY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBFYE-0282
Application
WB
Immunogen
Full length human recombiant protein of human EXOC4.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, glycerol, BSA
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Epitope
AA 1-110
More Infomation

Target

Full Name
exocyst complex component 4
Introduction
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Entrez Gene ID
Human60412
Mouse20336
Rat116654
UniProt ID
HumanQ96A65
MouseO35382
RatQ62824
Alternative Names
Exocyst Complex Component 4; Exocyst Complex Component Sec8; SEC8L1; SEC8; SEC8-Like 1 (S. Cerevisiae); SEC8-Like 1; KIAA1699; Sec8p
Research Area
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Biological Process
Chemical synaptic transmission Source: GO_Central
Exocytosis Source: GO_Central
Golgi to plasma membrane transport Source: GO_Central
Paraxial mesoderm formation Source: Ensembl
Protein transport Source: UniProtKB-KW
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Vesicle docking involved in exocytosis Source: InterPro
Vesicle tethering involved in exocytosis Source: InterPro
Cellular Location
Midbody ring; Cell projection. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes at the leading edge of migrating cells (By similarity).

Cullell, N., Soriano-Tárraga, C., Gallego-Fábrega, C., Cárcel-Márquez, J., Muiño, E., Llucià-Carol, L., ... & Fernández-Cadenas, I. (2022). Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study. Clinical epigenetics, 14(1), 1-17.

Li, H., Fu, X., Zhao, J., Li, C., Li, L., Xia, P., ... & Wang, X. (2022). EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal. Molecular Cancer Research, OF1-OF14.

He, Y., Zhou, X., Zheng, R., Jiang, Y., Yao, Z., Wang, X., ... & Yuan, X. (2021). The Association of an SNP in the EXOC4 gene and reproductive traits suggests its use as a breeding marker in pigs. Animals, 11(2), 521.

Semenova, E. I., Rudenok, M. M., Alieva, A. K., Karabanov, A. V., Illarioshkin, S. N., Slominsky, P. A., & Shadrina, M. I. (2021). Relative Levels of DNM2, EPN2, and EXOC4 Gene Expression in Peripheral Blood of Parkinson’s Disease Patients. Molecular Genetics, Microbiology and Virology, 36(3), 139-143.

Mamoor, S. (2021). EXOC4 is a differentially expressed gene in brain metastatic human breast cancer.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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