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F3

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Full Name

Coagulation Factor III, Tissue Factor

Research Area

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Biological Process

Activation of blood coagulation via clotting cascade Source: BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Activation of plasma proteins involved in acute inflammatory response Source: BHF-UCL
Blood coagulation Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Protein processing Source: BHF-UCL

Cellular Location

Isoform 1: Membrane
Isoform 2: Secreted

Topology

Extracellular: 33-251
Helical: 252-274
Cytoplasmic: 275-295

Anti-F3 antibodies

Rabbit Anti-F3 Recombinant Antibody (034) (CBMAB-C1721-LY)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 034

Application*: WB, E

Mouse Anti-F3 Recombinant Antibody (01) (CBMAB-C1584-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: 01

Application*: EC

Rat Anti-F3 Recombinant Antibody (355220) (CBMAB-C1022-LY)

SDS

Target: F3

Host: Rat

Antibody Isotype: IgG2c

Specificity: Mouse

Clone: 355220

Application*: WB

Rabbit Anti-F3 Recombinant Antibody (001) (CBMAB-C0017-LY)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 001

Application*: F

Mouse Anti-F3 Recombinant Antibody (GMA-320) (CBMAB-C4419-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: GMA-320

Application*: WB, E

Mouse Anti-F3 Recombinant Antibody (HTF-1) (CBMAB-C1775-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: HTF-1

Application*: F

Mouse Anti-F3 Recombinant Antibody (CLB/TF-1) (CBMAB-C0586-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CLB/TF-1

Application*: F, E

Mouse Anti-F3 Recombinant Antibody (CBYY-C0018) (CBMAB-C0043-YY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C0018

Application*: WB, IP, E(Cap)

Mouse Anti-F3 Recombinant Antibody (CBYJT-1272) (CBMAB-T0287-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYJT-1272

Application*: WB, IC, P, E

Mouse Anti-F3 Recombinant Antibody (CBYJT-1271) (CBMAB-T0286-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rabbit

Clone: CBYJT-1271

Application*: IC, P, E, WB

Mouse Anti-F3 Recombinant Antibody (CBYJT-1270) (CBMAB-T0285-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rabbit

Clone: CBYJT-1270

Application*: E, IC, IH, WB

Rat Anti-F3 Recombinant Antibody (CBYJT-1269) (CBMAB-T0284-YJ)

SDS

Target: F3

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-1269

Application*: WB, IC, P, E

Rabbit Anti-F3 Recombinant Antibody (CBYJT-1268) (CBMAB-T0283-YJ)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-1268

Application*: E, WB

Mouse Anti-F3 Recombinant Antibody (CBYJT-1267) (CBMAB-T0282-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJT-1267

Application*: WB, IP

Mouse Anti-F3 Recombinant Antibody (CBYJT-1265) (CBMAB-T0280-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1265

Application*: E, WB

Mouse Anti-F3 Recombinant Antibody (CBYJT-1264) (CBMAB-T0279-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-1264

Application*: E

Mouse Anti-F3 Recombinant Antibody (CBYJT-1263) (CBMAB-T0278-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1263

Application*: E, F, DB, IF, IH, WB

Mouse Anti-F3 Recombinant Antibody (CBYJT-1262) (CBMAB-T0277-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1262

Application*: E, IC, IH, WB

Mouse Anti-F3 Recombinant Antibody (CBYJT-1261) (CBMAB-T0276-YJ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1261

Application*: E, WB

Mouse Anti-F3 Recombinant Antibody (CBFYC-2637) (CBMAB-C2711-FY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2637

Application*: E, F, IF, IH, WB

Rabbit Anti-F3 Recombinant Antibody (CBFYC-2636) (CBMAB-C2710-FY)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-2636

Application*: E

Rabbit Anti-F3 Recombinant Antibody (CBFYC-2635) (CBMAB-C2709-FY)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-2635

Application*: WB, E

Mouse Anti-F3 Recombinant Antibody (CBFYC-2633) (CBMAB-C2707-FY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2633

Application*: F

Mouse Anti-F3 Recombinant Antibody (CBFYC-0126) (CBMAB-C0143-FY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-0126

Application*: E, F, IC, IF

Mouse Anti-F3 (Extracellular domain) Recombinant Antibody (TF9-10H10) (CBMAB-F2579-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: TF9-10H10

Application*: E, F, IF, C, WB

Mouse Anti-F3 Recombinant Antibody (CBXF-3778) (CBMAB-F2426-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXF-3778

Application*: E, IP, WB

Mouse Anti-F3 Recombinant Antibody (CBXF-2296) (CBMAB-F1585-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2296

Application*: E, WB

Mouse Anti-F3 Recombinant Antibody (CBXF-0167) (CBMAB-F0641-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-0167

Application*: E, WB

Mouse Anti-F3 Recombinant Antibody (CBXF-0168) (CBMAB-F0640-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBXF-0168

Application*: E, WB

Mouse Anti-F3 (AA 33-292) Recombinant Antibody (CBXF-0170) (CBMAB-F0265-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Rabbit

Clone: CBXF-0170

Application*: E, WB

Rabbit Anti-F3 (AA 30-251) Recombinant Antibody (CBXF-0165) (CBMAB-F0264-CQ)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXF-0165

Application*: E, IC, WB

Mouse Anti-F3 Recombinant Antibody (CBXF-0164) (CBMAB-F0262-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0164

Application*: E, F, IF, IH, WB

Mouse Anti-F3 Recombinant Antibody (CBXF-0163) (CBMAB-F0261-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0163

Application*: E, F

Mouse Anti-F3 (AA 34-251) Recombinant Antibody (CBXF-0169) (CBMAB-F0260-CQ)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0169

Application*: E, WB

Recombinant Mouse Anti-F3 Antibody (CBHb353) (CBMAB-Hb1027-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb353

Application*: FC, Immuno assays, WB

Rabbit Anti-F3 Recombinant Antibody (E2Y6L) (CBMAB-CP0662-LY)

SDS

Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: E2Y6L

Application*: WB, IF (IC), F

Mouse Anti-F3 Recombinant Antibody (10B759) (CBMAB-C3432-CN)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B759

Application*: E, FC

Mouse Anti-F3 Recombinant Antibody (CBYY-C1185) (CBMAB-C2622-YY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-C1185

Application*: E, WB

Rat Anti-F3 Recombinant Antibody (CBYY-C1184) (CBMAB-C2621-YY)

SDS

Target: F3

Host: Rat

Antibody Isotype: IgG2c

Specificity: Mouse

Clone: CBYY-C1184

Application*: WB

Mouse Anti-F3 Recombinant Antibody (5264) (CBMAB-C7154-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 5264

Application*: E, WB

Mouse Anti-F3 Recombinant Antibody (4G4) (CBMAB-C6994-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4G4

Application*: WB

Mouse Anti-F3 Recombinant Antibody (10B757) (CBMAB-C2267-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B757

Application*: E, F, IF, C, WB

Mouse Anti-F3 Recombinant Antibody (323519) (CBMAB-C0971-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 323519

Application*: WB, F, MC

Mouse Anti-F3 Recombinant Antibody (323514) (CBMAB-C0970-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 323514

Application*: WB, IP, EC

Mouse Anti-F3 Recombinant Antibody (05) (CBMAB-C0081-LY)

SDS

Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 05

Application*: E, F, IC/IF, IF

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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