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F3

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Full Name

Coagulation Factor III, Tissue Factor

Research Area

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Biological Process

Activation of blood coagulation via clotting cascade Source: BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Activation of plasma proteins involved in acute inflammatory response Source: BHF-UCL
Blood coagulation Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Protein processing Source: BHF-UCL

Cellular Location

Isoform 1: Membrane
Isoform 2: Secreted

Topology

Extracellular: 33-251
Helical: 252-274
Cytoplasmic: 275-295

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Anti-F3 antibodies

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Rabbit Anti-F3 Recombinant Antibody (034) (CBMAB-C1721-LY)

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Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 034

Application*: WB, E

Rabbit Anti-F3 Recombinant Antibody (001) (CBMAB-C0017-LY)

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Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 001

Application*: E

Rat Anti-F3 Recombinant Antibody (C1022) (V2LY-0825-LY1118)

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Target: F3

Host: Rat

Antibody Isotype: IgG2c

Specificity: Mouse

Clone: C1022

Application*: WB

Rabbit Anti-F3 Recombinant Antibody (CBXF-0165) (V2LY-0825-LY1110)

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Target: F3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-0165

Application*: P, IF, WB

Mouse Anti-F3 Recombinant Antibody (CBYJT-1264) (CBMAB-T0279-YJ)

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Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYJT-1264

Application*: E

Mouse Anti-F3 Recombinant Antibody (5264) (CBMAB-C7154-LY)

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Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5264

Application*: E, F, IF

Mouse Anti-F3 Recombinant Antibody (4G4) (CBMAB-C6994-LY)

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Target: F3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4G4

Application*: WB, IP, IF, E

Mouse Anti-F3 Recombinant Antibody (57) (CBMAB-C2267-LY)

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Target: F3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: 57

Application*: WB, IP, IF, E

Mouse Anti-F3 Recombinant Antibody (05) (CBMAB-C0081-LY)

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Target: F3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: 05

Application*: WB, IP, IF, E, P

Human Anti-F3 Recombinant Antibody (CBXF-0167) (CBMAB-F0641-CQ)

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Target: F3

Host: Human

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0167

Application*: E, F, IF, IH, B, in vivo

Mouse Anti-F3 Recombinant Antibody (CBXF-0168) (CBMAB-F0640-CQ)

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Target: F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-0168

Application*: WB, IH

Mouse Anti-F3 Recombinant Antibody (CBXF-0163) (CBMAB-F0261-CQ)

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Target: F3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0163

Application*: WB, F, IF, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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