Mouse Anti-F3 Recombinant Antibody (5264) (CBMAB-C7154-LY)

Name: Mouse Anti-F3 Recombinant Antibody (5264)
SKU: CBMAB-C7154-LY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-F3 Recombinant Antibody (5264) (CBMAB-C7154-LY) in FC

EC TF-1+ percentages (FACS) at different EVs stimuli conditions from three independent experiments. ...View More

Martínez-Rojas, P. P., Quiroz-García, E., Monroy-Martínez, V., Agredano-Moreno, L. T., Jiménez-García, L. F., & Ruiz-Ordaz, B. H. (2020). Participation of extracellular vesicles from zika-virus-infected mosquito cells in the modification of naïve cells' behavior by mediating cell-to-cell transmission of viral elements. Cells, 9(1), 123.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5264

Application

ELISA, FC, IF

Immunogen

Recombinant Human F3 / Tissue factor / CD142 protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:1,000-1:2,000
IF(ICC)	1:20-1:100
FC	1:25-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Coagulation Factor III, Tissue Factor

Introduction

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Entrez Gene ID

2152

UniProt ID

P13726

Alternative Names

Coagulation Factor III, Tissue Factor; Coagulation Factor III (Thromboplastin, Tissue Factor); Tissue Factor; TF; Coagulation Factor III; Thromboplastin; CD142 Antigen; CD142; TFA;

Research Area

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Biological Process

Activation of blood coagulation via clotting cascade Source: BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Activation of plasma proteins involved in acute inflammatory response Source: BHF-UCL
Blood coagulation Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Protein processing Source: BHF-UCL

Cellular Location

Isoform 1: Membrane
Isoform 2: Secreted

Topology

Extracellular: 33-251
Helical: 252-274
Cytoplasmic: 275-295

Mamoor, S. (2022). Differential expression of F3 in amyotrophic lateral sclerosis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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