FAM162A

FAM162A (Family With Sequence Similarity 162 Member A) is a Protein Coding gene. An important paralog of this gene is FAM162B.

Full Name

Family With Sequence Similarity 162 Member A

Research Area

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785).

May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785).

May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity).

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Cellular response to hypoxia Source: UniProtKB
Neuron apoptotic process Source: GO_Central
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB

Cellular Location

Mitochondrion membrane

Topology

Helical: 103-120