FBXO27

Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM

F-box protein 27

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Glycoprotein catabolic process Source: GO_Central
Protein ubiquitination Source: GOC
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Ubiquitin-dependent ERAD pathway Source: GO_Central

Cytosol; Cytoplasm; SCF ubiquitin ligase complex