FCGR3

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Full Name
Fc Fragment Of IgG Receptor IIIa
Research Area
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Cellular Location
Secreted; Cell membrane. Exists also as a soluble receptor.
Involvement in disease
Immunodeficiency 20 (IMD20):
A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
Topology
Extracellular: 17-208
Helical: 209-229
Cytoplasmic: 230-254
PTM
Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
The soluble form is produced by a proteolytic cleavage.
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Anti-FCGR3 antibodies

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Rat Anti-FCGR3 Recombinant Antibody (CBXC-1440) (CBMAB-C3297-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1440
Application*: F
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (CBXC-1683) (CBMAB-C3296-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1683
Application*: E, F
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (FCR4G8) (CBMAB-C3295-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: FCR4G8
Application*: F
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (CBXC-1445) (CBMAB-C2690-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1445
Application*: F, IF, IP
Datasheet SDS

Human Anti-FCGR3 Recombinant Antibody (CBXC-0830) (CBMAB-C1944-CQ)

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Target: FCGR3
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0830
Application*: F
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (CBXF-2927) (CBMAB-F3634-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-2927
Application*: F, WB
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (CBXF-2588) (CBMAB-F3027-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2588
Application*: WB
Datasheet SDS

Rabbit Anti-FCGR3 Recombinant Antibody (CBXF-0022) (CBMAB-F1206-CQ)

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Target: FCGR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-0022
Application*: F
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (2.4G2) (CBMAB-F0625-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 2.4G2
Application*: F, FN, IF, IP
Datasheet SDS

Rat Anti-FCGR3 Recombinant Antibody (CBXF-2587) (CBMAB-F0136-CQ)

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Target: FCGR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2587
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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