FGF10

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq]

fibroblast growth factor 10

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Actin cytoskeleton reorganization Source: UniProtKB
Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: Ensembl
Animal organ morphogenesis Source: GO_Central
Blood vessel remodeling Source: Ensembl
Branch elongation involved in salivary gland morphogenesis Source: Ensembl
Branching morphogenesis of an epithelial tube Source: UniProtKB
Bronchiole morphogenesis Source: Ensembl
Bud elongation involved in lung branching Source: Ensembl
Bud outgrowth involved in lung branching Source: MGI
Cell differentiation Source: GO_Central
Determination of left/right symmetry Source: Ensembl
Embryonic camera-type eye development Source: Ensembl
Embryonic digestive tract morphogenesis Source: Ensembl
Embryonic genitalia morphogenesis Source: Ensembl
Embryonic pattern specification Source: Ensembl
Epithelial cell proliferation Source: UniProtKB
Epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
ERK1 and ERK2 cascade Source: UniProtKB
Establishment of mitotic spindle orientation Source: Ensembl
Female genitalia morphogenesis Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
Hair follicle morphogenesis Source: Ensembl
Harderian gland development Source: Ensembl
Induction of positive chemotaxis Source: Ensembl
Lacrimal gland development Source: UniProtKB
Limb bud formation Source: Ensembl
Limb development Source: GO_Central
Lung epithelium development Source: MGI
Lung proximal/distal axis specification Source: Ensembl
Lung saccule development Source: UniProtKB
Male genitalia morphogenesis Source: Ensembl
Mammary gland bud formation Source: Ensembl
Mesenchymal cell differentiation involved in lung development Source: Ensembl
Mesenchymal-epithelial cell signaling involved in lung development Source: Ensembl
Mesonephros development Source: UniProtKB
Metanephros development Source: UniProtKB
Metanephros morphogenesis Source: Ensembl
Muscle cell fate commitment Source: Ensembl
Negative regulation of cell differentiation Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Organ induction Source: Ensembl
Otic vesicle formation Source: Ensembl
Pancreas development Source: Ensembl
Pituitary gland development Source: Ensembl
Positive chemotaxis Source: UniProtKB
Positive regulation of ATPase activity Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of DNA repair Source: UniProtKB
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of epithelial cell proliferation Source: UniProtKB
Positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of hair follicle cell proliferation Source: UniProtKB
Positive regulation of keratinocyte migration Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of lymphocyte proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of Notch signaling pathway Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of Ras protein signal transduction Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of urothelial cell proliferation Source: UniProtKB
Positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Positive regulation of white fat cell proliferation Source: Ensembl
Prostatic bud formation Source: Ensembl
Protein localization to cell surface Source: UniProtKB
Radial glial cell differentiation Source: UniProtKB
Regulation of activin receptor signaling pathway Source: Ensembl
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
Regulation of cell cycle Source: UniProtKB
Regulation of cell migration Source: GO_Central
Regulation of saliva secretion Source: UniProtKB
Regulation of smoothened signaling pathway Source: Ensembl
Response to estradiol Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Salivary gland development Source: UniProtKB
Secretion by lung epithelial cell involved in lung growth Source: UniProtKB
Semicircular canal fusion Source: Ensembl
Smooth muscle cell differentiation Source: Ensembl
Somatic stem cell population maintenance Source: Ensembl
Spleen development Source: Ensembl
Submandibular salivary gland formation Source: Ensembl
Tear secretion Source: UniProtKB
Thymus development Source: UniProtKB
Thyroid gland development Source: Ensembl
Tissue regeneration Source: Ensembl
Type II pneumocyte differentiation Source: Ensembl
Urothelial cell proliferation Source: UniProtKB
White fat cell differentiation Source: Ensembl
Wound healing Source: UniProtKB

Secreted

Aplasia of lacrimal and salivary glands (ALSG):
A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.
Lacrimo-auriculo-dento-digital syndrome (LADDS):
An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.