FGF7

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

Full Name

Fibroblast Growth Factor 7

Research Area

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Animal organ morphogenesis Source: GO_Central
Branching involved in salivary gland morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Epidermis development Source: ProtInc
Fibroblast growth factor receptor signaling pathway Source: MGI
Hair follicle morphogenesis Source: Ensembl
Lung development Source: GO_Central
Mesenchymal cell proliferation Source: UniProtKB
Positive chemotaxis Source: UniProtKB
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of epithelial cell proliferation Source: UniProtKB
Positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of keratinocyte migration Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: GO_Central
Protein localization to cell surface Source: UniProtKB
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
Regulation of cell migration Source: GO_Central
Response to wounding Source: ProtInc
Secretion by lung epithelial cell involved in lung growth Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Secreted