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Mouse Anti-FGF7 Recombinant Antibody (5J2) (CBMAB-K0341-LY)

This product is antibody recognizes FGF7. The antibody 5J2 immunoassay techniques such as: WB.
See all FGF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5J2
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
1% BSA
Preservative
0.05% NaN3
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fibroblast Growth Factor 7
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2252
UniProt ID
P21781
Alternative Names
Fibroblast Growth Factor 7; Keratinocyte Growth Factor; Heparin-Binding Growth Factor 7; HBGF-7; FGF-7; KGF; Fibroblast Growth Factor 7 (Keratinocyte Growth Factor);
Research Area
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Biological Process
Actin cytoskeleton reorganization Source: UniProtKB
Animal organ morphogenesis Source: GO_Central
Branching involved in salivary gland morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Epidermis development Source: ProtInc
Fibroblast growth factor receptor signaling pathway Source: MGI
Hair follicle morphogenesis Source: Ensembl
Lung development Source: GO_Central
Mesenchymal cell proliferation Source: UniProtKB
Positive chemotaxis Source: UniProtKB
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of epithelial cell proliferation Source: UniProtKB
Positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of keratinocyte migration Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: GO_Central
Protein localization to cell surface Source: UniProtKB
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
Regulation of cell migration Source: GO_Central
Response to wounding Source: ProtInc
Secretion by lung epithelial cell involved in lung growth Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Secreted

Takaya, K., Aramaki-Hattori, N., Sakai, S., Okabe, K., Asou, T., & Kishi, K. (2022). Fibroblast Growth Factor 7 Suppresses Fibrosis and Promotes Epithelialization during Wound Healing in Mouse Fetuses. International journal of molecular sciences, 23(13), 7087.

Mei, L., Chen, Y., Chen, P., Chen, H., He, S., Jin, C., ... & Guan, X. (2022). Fibroblast growth factor 7 alleviates myocardial infarction by improving oxidative stress via PI3Kα/AKT-mediated regulation of Nrf2 and HXK2. Redox Biology, 56, 102468.

Lian, A. A., Yamaji, Y., Kajiwara, K., Takaki, K., Mori, H., Liew, M. W. O., ... & Maruta, R. (2022). A Bioengineering Approach for the Development of Fibroblast Growth Factor-7-Functionalized Sericin Biomaterial Applicable for the Cultivation of Keratinocytes. International Journal of Molecular Sciences, 23(17), 9953.

Li, T., Qing, B. L., Deng, Y., Que, X. T., Wang, C. Z., Lu, H. W., ... & Wang, Z. J. (2022). Inhibition of Long non-coding RNA zinc finger antisense 1 improves functional recovery and angiogenesis after focal cerebral ischemia via microRNA-144-5p/fibroblast growth factor 7 axis. Bioengineered, 13(1), 1702-1716.

Alwahsh, S. M., Qutachi, O., Starkey Lewis, P. J., Bond, A., Noble, J., Burgoyne, P., ... & Forbes, S. (2021). Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes. American Journal of Transplantation, 21(9), 2950-2963.

Alam, M., Bertolini, M., Gherardini, J., Keren, A., Ponce, L., Chéret, J., ... & Paus, R. (2020). An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes. British Journal of Dermatology, 182(6), 1404-1414.

Zhang, C., Han, M., & Wu, S. (2019). Silencing fibroblast growth factor 7 inhibits krypton laser‐induced choroidal neovascularization in a rat model. Journal of Cellular Biochemistry, 120(8), 13792-13801.

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., ... & Carvalho, E. (2019). microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation. Scientific reports, 9(1), 1-11.

Patel, A., Tripathi, G., McTernan, P., Gopalakrishnan, K., Ali, O., Spector, E., ... & Arasaradnam, R. P. (2019). Fibroblast growth factor 7 signalling is disrupted in colorectal cancer and is a potential marker of field cancerisation. Journal of Gastrointestinal Oncology, 10(3), 429-436.

Nguyen, D., & Sulaiman, O. A. (2019). Transforming growth factor beta 1 regulates fibroblast growth factor 7 expression in Schwann cells. Ochsner Journal, 19(1), 7-12.

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For research use only. Not intended for any clinical use.

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