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FRMPD4

FRMPD4 is a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.

Full Name

FERM And PDZ Domain Containing 4

Function

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.

Biological Process

Positive regulation of synapse structural plasticity Source: UniProtKB

Cellular Location

Dendritic spine

Involvement in disease

Mental retardation, X-linked 104 (MRX104):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

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Anti-FRMPD4 antibodies

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Mouse Anti-FRMPD4 Recombinant Antibody (CBXF-3198) (CBMAB-F3894-CQ)

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Target: FRMPD4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBXF-3198

Application*: E, WB

Mouse Anti-FRMPD4 Recombinant Antibody (CBXF-3198) (V2LY-1225-LY104)

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Target: FRMPD4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBXF-3198

Application*: WB

Mouse Anti-FRMPD4 Recombinant Antibody (CBYC-P069) (CBMAB-P0350-YC)

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Target: FRMPD4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBYC-P069

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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