Mouse Anti-FRMPD4 Recombinant Antibody (CBXF-3198) (CBMAB-F3894-CQ)

Name: Mouse Anti-FRMPD4 Recombinant Antibody (CBXF-3198)
SKU: CBMAB-F3894-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse

Clone

CBXF-3198

Antibody Isotype

IgG2b

Application

ELISA, WB

Basic Information

Immunogen

Recombinant protein corresponding to aa890-1022 from human Preso/FRMPD4, expressed in E. coli (UniProt # Q14CM0)

Specificity

Human, Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

FERM And PDZ Domain Containing 4

Introduction

This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.

Entrez Gene ID

Human	9758
Mouse	333605

UniProt ID

Human	Q14CM0
Mouse	A2AFR3

Alternative Names

FERM And PDZ Domain Containing 4; PSD-95-Interacting Regulator Of Spine Morphogenesis; PDZ Domain-Containing Protein 10; PDZD10; PDZK10; Preso;

Function

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.

Biological Process

Positive regulation of synapse structural plasticity Source: UniProtKB

Cellular Location

Dendritic spine

Involvement in disease

Mental retardation, X-linked 104 (MRX104):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

More Infomation

References

Wang, M., Lin, L., Shi, Y., He, L., Wang, C., & Zhu, J. (2020). Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochemical Journal, 477(23), 4623-4634.

Piard, J., Hu, J. H., Campeau, P. M., Rzońca, S., Van Esch, H., Vincent, E., ... & Worley, P. F. (2018). FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Human molecular genetics, 27(4), 589-600.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-FRMPD4 Recombinant Antibody (CBYC-P069)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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