FST
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Full Name
Follistatin
Function
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Biological Process
BMP signaling pathway Source: Ensembl
Cell differentiation Source: GO_Central
Female gonad development Source: Ensembl
Gamete generation Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Keratinocyte proliferation Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of cell differentiation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Pattern specification process Source: Ensembl
Positive regulation of hair follicle development Source: MGI
Regulation of BMP signaling pathway Source: GO_Central
Skeletal system development Source: Ensembl
Cell differentiation Source: GO_Central
Female gonad development Source: Ensembl
Gamete generation Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Keratinocyte proliferation Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of cell differentiation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Pattern specification process Source: Ensembl
Positive regulation of hair follicle development Source: MGI
Regulation of BMP signaling pathway Source: GO_Central
Skeletal system development Source: Ensembl
Cellular Location
Secreted
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Anti-FST antibodies
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Target: FST
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 1689
Application*: ELISA, IF, IHC, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B11
Application*: WB, E
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 29/9
Application*: E
Target: FST
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXF-1689
Application*: IH, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3212
Application*: E, WB
Target: FST
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXF-3211
Application*: E, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3210
Application*: E, IH, WB
Target: FST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-1954
Application*: WB
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXF-0933
Application*: E, WB, IF
Target: FST
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXF-0935
Application*: E, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXF-2183
Application*: P, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: H10
Application*: E, P, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 17/2
Application*: E, P, WB
Target: FST
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXF-2342
Application*: E, WB, IH, IF
Target: FST
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0936
Application*: WB, IC, P, C, E
Target: FST
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXF-0934
Application*: WB, E
Target: FST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-1083
Application*: WB
Target: FST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2677
Application*: WB, IH
Target: FST
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: His Tag
Target: FST
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-317
Tag: hFc Tag
Target: FST
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-317
Tag: His Tag
Target: FST
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-329
Tag: His Tag
Target: FST
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: hFc Tag
Target: FST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3211
Application*: WB, IH
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3210
Application*: E
Target: FST
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-0933
Application*: E
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0935
Application*: E, P
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2183
Application*: WB, E, IF
Target: FST
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2342
Application*: WB, IP, IF, E
Target: FST
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0936
Application*: WB, IP, IF, E
Target: FST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXF-2677
Application*: WB
Target: FST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF174
Application*: ELISA, WB, IHC, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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