Mouse Anti-FST Recombinant Antibody (CBXF-1954) (CBMAB-F2792-CQ)

Name: Mouse Anti-FST Recombinant Antibody (CBXF-1954)
SKU: CBMAB-F2792-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1954

Application

WB, IHC-P

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Follistatin

Introduction

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

Entrez Gene ID

10468

UniProt ID

P19883

Alternative Names

Follistatin; Activin-Binding Protein; FS; Follistatin Isoform FST317;

Function

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Biological Process

BMP signaling pathway Source: Ensembl
Cell differentiation Source: GO_Central
Female gonad development Source: Ensembl
Gamete generation Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Keratinocyte proliferation Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of cell differentiation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Pattern specification process Source: Ensembl
Positive regulation of hair follicle development Source: MGI
Regulation of BMP signaling pathway Source: GO_Central
Skeletal system development Source: Ensembl

Cellular Location

Secreted

Chen, Y. J., Deng, S. M., Chen, H. W., Tsao, C. H., Chen, W. T., Cheng, S. J., ... & Huang, G. J. (2021). Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus. Proceedings of the National Academy of Sciences, 118(39), e2109040118.

Panagiotou, G., Ghaly, W., Upadhyay, J., Pazaitou-Panayiotou, K., & Mantzoros, C. S. (2021). Serum follistatin is increased in thyroid cancer and is associated with Adverse tumor characteristics in humans. The Journal of Clinical Endocrinology & Metabolism, 106(5), e2137-e2150.

Pervin, S., Reddy, S. T., & Singh, R. (2021). Novel roles of follistatin/myostatin in transforming growth factor-β signaling and adipose browning: Potential for therapeutic intervention in obesity related metabolic disorders. Frontiers in Endocrinology, 12, 653179.

Sylow, L., Vind, B. F., Kruse, R., Møller, P. M., Wojtaszewski, J. F., Richter, E. A., & Højlund, K. (2020). Circulating follistatin and activin A and their regulation by insulin in obesity and type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism, 105(5), 1343-1354.

Motahari Rad, M., Bijeh, N., Attarzadeh Hosseini, S. R., & Raouf Saeb, A. (2020). The effect of two concurrent exercise modalities on serum concentrations of FGF21, irisin, follistatin, and myostatin in men with type 2 diabetes mellitus. Archives of Physiology and Biochemistry, 1-10.

Han, X., Møller, L. L. V., De Groote, E., Bojsen‐Møller, K. N., Davey, J., Henríquez‐Olguin, C., ... & Sylow, L. (2019). Mechanisms involved in follistatin‐induced hypertrophy and increased insulin action in skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, 10(6), 1241-1257.

Mehta, N., Gava, A. L., Zhang, D., Gao, B., & Krepinsky, J. C. (2019). Follistatin protects against glomerular mesangial cell apoptosis and oxidative stress to ameliorate chronic kidney disease. Antioxidants & redox signaling, 31(8), 551-571.

Singh, R., Pervin, S., Lee, S. J., Kuo, A., Grijalva, V., David, J., ... & Reddy, S. T. (2018). Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 65-84.

Zhang, L., Liu, K., Han, B., Xu, Z., & Gao, X. (2018). The emerging role of follistatin under stresses and its implications in diseases. Gene, 639, 111-116.

Tao, R., Wang, C., Stöhr, O., Qiu, W., Hu, Y., Miao, J., ... & White, M. F. (2018). Inactivating hepatic follistatin alleviates hyperglycemia. Nature medicine, 24(7), 1058-1069.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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