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Mouse Anti-FST Recombinant Antibody (CBXF-2677) (CBMAB-F0177-CQ)

This product is a mouse antibody that recognizes FST. The antibody CBXF-2677 can be used for immunoassay techniques such as: WB, IHC.
See all FST antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2677
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Sf 21-derived recombinant human Follistatin, Gly30-Asp329, Accession # P19883
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Follistatin
Introduction
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Entrez Gene ID
10468
UniProt ID
P19883
Alternative Names
Follistatin; Activin-Binding Protein; FS; Follistatin Isoform FST317;
Function
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Biological Process
BMP signaling pathway Source: Ensembl
Cell differentiation Source: GO_Central
Female gonad development Source: Ensembl
Gamete generation Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Keratinocyte proliferation Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of cell differentiation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Pattern specification process Source: Ensembl
Positive regulation of hair follicle development Source: MGI
Regulation of BMP signaling pathway Source: GO_Central
Skeletal system development Source: Ensembl
Cellular Location
Secreted

Chen, Y. J., Deng, S. M., Chen, H. W., Tsao, C. H., Chen, W. T., Cheng, S. J., ... & Huang, G. J. (2021). Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus. Proceedings of the National Academy of Sciences, 118(39), e2109040118.

Panagiotou, G., Ghaly, W., Upadhyay, J., Pazaitou-Panayiotou, K., & Mantzoros, C. S. (2021). Serum follistatin is increased in thyroid cancer and is associated with Adverse tumor characteristics in humans. The Journal of Clinical Endocrinology & Metabolism, 106(5), e2137-e2150.

Pervin, S., Reddy, S. T., & Singh, R. (2021). Novel roles of follistatin/myostatin in transforming growth factor-β signaling and adipose browning: Potential for therapeutic intervention in obesity related metabolic disorders. Frontiers in Endocrinology, 12, 653179.

Sylow, L., Vind, B. F., Kruse, R., Møller, P. M., Wojtaszewski, J. F., Richter, E. A., & Højlund, K. (2020). Circulating follistatin and activin A and their regulation by insulin in obesity and type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism, 105(5), 1343-1354.

Motahari Rad, M., Bijeh, N., Attarzadeh Hosseini, S. R., & Raouf Saeb, A. (2020). The effect of two concurrent exercise modalities on serum concentrations of FGF21, irisin, follistatin, and myostatin in men with type 2 diabetes mellitus. Archives of Physiology and Biochemistry, 1-10.

Han, X., Møller, L. L. V., De Groote, E., Bojsen‐Møller, K. N., Davey, J., Henríquez‐Olguin, C., ... & Sylow, L. (2019). Mechanisms involved in follistatin‐induced hypertrophy and increased insulin action in skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, 10(6), 1241-1257.

Mehta, N., Gava, A. L., Zhang, D., Gao, B., & Krepinsky, J. C. (2019). Follistatin protects against glomerular mesangial cell apoptosis and oxidative stress to ameliorate chronic kidney disease. Antioxidants & redox signaling, 31(8), 551-571.

Singh, R., Pervin, S., Lee, S. J., Kuo, A., Grijalva, V., David, J., ... & Reddy, S. T. (2018). Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 65-84.

Zhang, L., Liu, K., Han, B., Xu, Z., & Gao, X. (2018). The emerging role of follistatin under stresses and its implications in diseases. Gene, 639, 111-116.

Tao, R., Wang, C., Stöhr, O., Qiu, W., Hu, Y., Miao, J., ... & White, M. F. (2018). Inactivating hepatic follistatin alleviates hyperglycemia. Nature medicine, 24(7), 1058-1069.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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