FXYD5

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.

Full Name

FXYD Domain Containing Ion Transport Regulator 5

Function

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.

Biological Process

Ion transport Source: UniProtKB-KW
Microvillus assembly Source: UniProtKB
Negative regulation of calcium-dependent cell-cell adhesion Source: UniProtKB
Regulation of sodium ion transmembrane transporter activity Source: GO_Central

Cellular Location

Membrane

Topology

Extracellular: 22-145
Helical: 146-164
Cytoplasmic: 165-178

PTM

Glycosylated.