GALNT2

This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgiapparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants.
Full Name
Polypeptide N-Acetylgalactosaminyltransferase 2
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671).
Biological Process
O-glycan processing Source: GO_Central
Protein maturation Source: BHF-UCL
Protein O-linked glycosylation Source: UniProtKB
Protein O-linked glycosylation via serine Source: BHF-UCL
Protein O-linked glycosylation via threonine Source: BHF-UCL
Cellular Location
Secreted; Golgi stack membrane. Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
Topology
Cytoplasmic: 1-6
Helical: 7-24
Lumenal: 25-571
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Anti-GALNT2 antibodies

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Mouse Anti-GALNT2 Recombinant Antibody (1501421) (CBMAB-G1861-LY)

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Target: GALNT2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1501421
Application*: WB
Datasheet SDS

Human GALNT2 ELISA Kit (V2LY-0626-LY5741)

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Target: GALNT2
Sensitivity: 0.18 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant GALNT2 protein, His Tag (V2LY-0526-LY4255)

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Target: GALNT2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 52-571
Tag: His Tag
Datasheet SDS

Mouse Anti-GALNT2 Recombinant Antibody (G1861) (V2LY-1225-LY628)

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Target: GALNT2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: G1861
Application*: WB, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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