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Mouse Anti-GALNT2 Recombinant Antibody (1501421) (CBMAB-G1861-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1501421
Antibody Isotype
IgG2b, κ
Application
WB

Basic Information

Immunogen
Recombinant Human GALNT2
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Polypeptide N-Acetylgalactosaminyltransferase 2
Introduction
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Entrez Gene ID
2590
UniProt ID
Q10471
Alternative Names
Polypeptide N-Acetylgalactosaminyltransferase 2; Polypeptide GalNAc Transferase 2; UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2); UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 2; Pp-GaNTase 2; EC 2.4.1.41; GalNAc-T2; Protein-UDP Acetylgalactosaminyltransferase 2;
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671).
Biological Process
O-glycan processing Source: GO_Central
Protein maturation Source: BHF-UCL
Protein O-linked glycosylation Source: UniProtKB
Protein O-linked glycosylation via serine Source: BHF-UCL
Protein O-linked glycosylation via threonine Source: BHF-UCL
Cellular Location
Secreted; Golgi stack membrane. Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
Topology
Cytoplasmic: 1-6
Helical: 7-24
Lumenal: 25-571
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For research use only. Not intended for any clinical use.

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