Mouse Anti-GALNT2 Recombinant Antibody (1501421) (CBMAB-G1861-LY)

Name: Mouse Anti-GALNT2 Recombinant Antibody (1501421)
SKU: CBMAB-G1861-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1501421

Application

Immunogen

Recombinant Human GALNT2

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Polypeptide N-Acetylgalactosaminyltransferase 2

Introduction

This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Entrez Gene ID

2590

UniProt ID

Q10471

Alternative Names

Polypeptide N-Acetylgalactosaminyltransferase 2; Polypeptide GalNAc Transferase 2; UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2); UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 2; Pp-GaNTase 2; EC 2.4.1.41; GalNAc-T2; Protein-UDP Acetylgalactosaminyltransferase 2;

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671).

Biological Process

O-glycan processing Source: GO_Central
Protein maturation Source: BHF-UCL
Protein O-linked glycosylation Source: UniProtKB
Protein O-linked glycosylation via serine Source: BHF-UCL
Protein O-linked glycosylation via threonine Source: BHF-UCL

Cellular Location

Secreted; Golgi stack membrane. Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.

Topology

Cytoplasmic: 1-6
Helical: 7-24
Lumenal: 25-571

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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