GBA3

The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants.
Full Name
Glucosylceramidase Beta 3 (Gene/Pseudogene)
Function
Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169).

Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169).

However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381).

Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169).

However, the in vivo relevance of these activities is unclear (PubMed:17595169).

It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319).

Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330).
Biological Process
Beta-glucoside catabolic process Source: UniProtKB
Cellular oligosaccharide catabolic process Source: CAFA
Galactosylceramide catabolic process Source: UniProtKB
Glucosylceramide catabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Glycosylceramide catabolic process Source: GO_Central
Positive regulation of exo-alpha-sialidase activity Source: CAFA
Protein stabilization Source: CAFA
Cellular Location
Cytosol
PTM
The N-terminus is blocked.
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Anti-GBA3 antibodies

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Mouse Anti-GBA3 Recombinant Antibody (CBXC-1306) (CBMAB-C5735-CQ)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1306
Application*: WB
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBXC-1305) (CBMAB-C5734-CQ)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1305
Application*: IC
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBFYC-2718) (CBMAB-C2792-FY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2718
Application*: IF
Datasheet SDS

Rabbit Anti-GBA3 Recombinant Antibody (CBLG1-715) (CBMAB-G2375-LY)

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Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-715
Application*: IF
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-714) (CBMAB-G2374-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-714
Application*: IF
Datasheet SDS

Rabbit Anti-GBA3 Recombinant Antibody (CBLG1-713) (CBMAB-G2373-LY)

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Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-713
Application*: E
Datasheet SDS

Rabbit Anti-GBA3 Recombinant Antibody (CBLG1-712) (CBMAB-G2372-LY)

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Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-712
Application*: F
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2641) (CBMAB-G2370-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2641
Application*: E, LA
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2639) (CBMAB-G2368-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2639
Application*: WB
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2638) (CBMAB-G2367-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2638
Application*: E
Datasheet SDS

Rabbit Anti-GBA3 Recombinant Antibody (8) (CBMAB-G2366-LY)

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Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8
Application*: IF/IC
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (728702) (CBMAB-G2365-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 728702
Application*: IC, IF
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (5G5) (CBMAB-G2364-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G5
Application*: WB
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (4F10) (CBMAB-G2361-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4F10
Application*: F
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (3E8) (CBMAB-G2359-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E8
Application*: P, WB
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (1C7) (CBMAB-G2357-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7
Application*: F
Datasheet SDS

Rabbit Anti-GBA3 Recombinant Antibody (19) (CBMAB-G2356-LY)

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Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 19
Application*: IF, F
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-048) (CBMAB-G0247-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-048
Application*: F
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2637) (CBMAB-G0246-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2637
Application*: WB
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2636) (CBMAB-G0245-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2636
Application*: E
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2635) (CBMAB-G0244-LY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2635
Application*: WB
Datasheet SDS

Mouse Anti-GBA3 (AA 1-150) Recombinant Antibody (CBFYH-0265) (CBMAB-H1139-FY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0265
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-GBA3 (AA 1-150) Recombinant Antibody (CBFYH-0264) (CBMAB-H1138-FY)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0264
Application*: F, WB
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2638) (V2LY-1225-LY815)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2638
Application*: WB, IH, F
Datasheet SDS

Rabbit Anti-GBA3 Recombinant Antibody (8) (V2LY-1225-LY814)

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Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8
Application*: E
Datasheet SDS

Mouse Anti-GBA3 Recombinant Antibody (CBFYH-0264) (V2LY-1225-LY812)

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Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0264
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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