GBA3
The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants.
Full Name
Glucosylceramidase Beta 3 (Gene/Pseudogene)
Function
Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169).
Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169).
However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381).
Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169).
However, the in vivo relevance of these activities is unclear (PubMed:17595169).
It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319).
Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330).
Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169).
However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381).
Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169).
However, the in vivo relevance of these activities is unclear (PubMed:17595169).
It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319).
Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330).
Biological Process
Beta-glucoside catabolic process Source: UniProtKB
Cellular oligosaccharide catabolic process Source: CAFA
Galactosylceramide catabolic process Source: UniProtKB
Glucosylceramide catabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Glycosylceramide catabolic process Source: GO_Central
Positive regulation of exo-alpha-sialidase activity Source: CAFA
Protein stabilization Source: CAFA
Cellular oligosaccharide catabolic process Source: CAFA
Galactosylceramide catabolic process Source: UniProtKB
Glucosylceramide catabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Glycosylceramide catabolic process Source: GO_Central
Positive regulation of exo-alpha-sialidase activity Source: CAFA
Protein stabilization Source: CAFA
Cellular Location
Cytosol
PTM
The N-terminus is blocked.
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Anti-GBA3 antibodies
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CompareTarget: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1306
Application*: WB
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1305
Application*: IC
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2718
Application*: WB, F, IH, P
Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-715
Application*: IF
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-714
Application*: IF
Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-713
Application*: E
Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-712
Application*: F
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2641
Application*: E, LA
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2639
Application*: WB
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2638
Application*: E
Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8
Application*: IF/IC
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 728702
Application*: IC, IF
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G5
Application*: WB
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4F10
Application*: F
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E8
Application*: P, WB
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7
Application*: F
Target: GBA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 19
Application*: E
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-048
Application*: F
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2637
Application*: WB
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2636
Application*: E
Target: GBA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2635
Application*: WB
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0265
Application*: WB, IH, F
Target: GBA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0264
Application*: F, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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