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Mouse Anti-GBA3 Recombinant Antibody (CBLG1-2639) (CBMAB-G2368-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBLG1-2639
Application
WB
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-150 and 370-469 of human GBA3(NP_066024) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.74 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Glucosylceramidase Beta 3 (Gene/Pseudogene)
Introduction
The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Entrez Gene ID
57733
UniProt ID
Q9H227
Alternative Names
Glucosylceramidase Beta 3 (Gene/Pseudogene); Cytosolic Beta-Glucosidase-Like Protein 1; Glucosidase; Beta; Acid 3 (Cytosolic); Klotho-Related Protein; EC 3.2.1.21; CBGL1;
Function
Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169).

Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169).

However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381).

Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169).

However, the in vivo relevance of these activities is unclear (PubMed:17595169).

It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319).

Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330).
Biological Process
Beta-glucoside catabolic process Source: UniProtKB
Cellular oligosaccharide catabolic process Source: CAFA
Galactosylceramide catabolic process Source: UniProtKB
Glucosylceramide catabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Glycosylceramide catabolic process Source: GO_Central
Positive regulation of exo-alpha-sialidase activity Source: CAFA
Protein stabilization Source: CAFA
Cellular Location
Cytosol
PTM
The N-terminus is blocked.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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