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GCFC2

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.

Full Name

GC-rich sequence DNA-binding factor 2

Function

Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693).

May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693).

Biological Process

mRNA splicing, via spliceosome Source: GO_Central
Negative regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Spliceosomal complex assembly Source: UniProtKB

Cellular Location

Nucleoplasm; Nucleolus

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Anti-GCFC2 antibodies

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Rabbit Anti-GCFC2 Recombinant Antibody (EG1298) (CBMAB-EN1569-LY)

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Target: GCFC2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1298

Application*: WB: 1:500~1:1000 ELISA: 1:20000

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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