GCNT3
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Full Name
Glucosaminyl (N-Acetyl) Transferase 3, Mucin Type
Function
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
Biological Process
Carbohydrate metabolic process Source: ProtInc
Intestinal absorption Source: Ensembl
Kidney morphogenesis Source: Ensembl
O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: ProtInc
Tissue morphogenesis Source: Ensembl
Intestinal absorption Source: Ensembl
Kidney morphogenesis Source: Ensembl
O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: ProtInc
Tissue morphogenesis Source: Ensembl
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-6
Helical: 7-26
Lumenal: 27-438
Helical: 7-26
Lumenal: 27-438
PTM
N-glycosylated.
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Anti-GCNT3 antibodies
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Target: GCNT3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3157
Application*: WB
Target: GCNT3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-3157
Application*: WB, IP, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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