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GCNT3

This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]

Full Name

Glucosaminyl (N-Acetyl) Transferase 3, Mucin Type

Function

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.

Biological Process

Carbohydrate metabolic process Source: ProtInc
Intestinal absorption Source: Ensembl
Kidney morphogenesis Source: Ensembl
O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: ProtInc
Tissue morphogenesis Source: Ensembl

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-6
Helical: 7-26
Lumenal: 27-438

PTM

N-glycosylated.

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Anti-GCNT3 antibodies

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Mouse Anti-GCNT3 Recombinant Antibody (CBLG1-3157) (CBMAB-G2664-LY)

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Target: GCNT3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3157

Application*: WB

Mouse Anti-GCNT3 Recombinant Antibody (CBLG1-3157) (V2LY-1225-LY938)

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Target: GCNT3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-3157

Application*: WB, IP, IF, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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