GCNT3

This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]

Full Name

Glucosaminyl (N-Acetyl) Transferase 3, Mucin Type

Function

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.

Biological Process

Carbohydrate metabolic process Source: ProtInc
Intestinal absorption Source: Ensembl
Kidney morphogenesis Source: Ensembl
O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: ProtInc
Tissue morphogenesis Source: Ensembl

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-6
Helical: 7-26
Lumenal: 27-438

PTM

N-glycosylated.