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GGH

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

Full Name

Gamma-Glutamyl Hydrolase

Function

Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.

Biological Process

Poly-gamma-glutamate metabolic process Source: Ensembl
Response to drug Source: Ensembl
Response to ethanol Source: Ensembl
Response to insulin Source: Ensembl
Response to zinc ion Source: Ensembl
Tetrahydrofolylpolyglutamate metabolic process Source: GO_Central

Cellular Location

Lysosome; Extracellular space; Melanosome. While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

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Anti-GGH antibodies

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Rabbit Anti-GGH Recombinant Antibody (EG1308) (CBMAB-EN1584-LY)

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Target: GGH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1308

Application*: WB: 1:500~1:1000 ELISA: 1:10000

Human Recombinant GGH protein, His Tag (V2LY-0526-LY4300)

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Target: GGH

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-318

Tag: His Tag

Rabbit Anti-GGH Recombinant Antibody (EG1308) (V2LY-1225-LY1169)

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Target: GGH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1308

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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