GIF

This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq]
Full Name
gastric intrinsic factor (vitamin B synthesis)
Function
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Biological Process
Cobalamin transport Source: UniProtKB
Cobalt ion transport Source: UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Hereditary intrinsic factor deficiency (IFD):
Autosomal recessive disorder characterized by megaloblastic anemia.
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Anti-GIF antibodies

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Mouse Anti-GIF Recombinant Antibody (CBLG1-1161) (CBMAB-G3482-LY)

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Target: GIF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1161
Application*: WB
Datasheet SDS

Mouse Anti-GIF Recombinant Antibody (CBLG1-1160) (CBMAB-G3481-LY)

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Target: GIF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1160
Application*: WB
Datasheet SDS

Rabbit Anti-GIF Recombinant Antibody (CBLG1-1159) (CBMAB-G3480-LY)

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Target: GIF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1159
Application*: E, EC
Datasheet SDS

Rabbit Anti-GIF Recombinant Antibody (CBLG1-1158) (CBMAB-G3479-LY)

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Target: GIF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1158
Application*: WB
Datasheet SDS

Rabbit Anti-GIF Recombinant Antibody (CBLG1-1157) (CBMAB-G3478-LY)

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Target: GIF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1157
Application*: F
Datasheet SDS

Mouse Anti-GIF Recombinant Antibody (1D9) (CBMAB-G3475-LY)

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Target: GIF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D9
Application*: E, IF, IP
Datasheet SDS

Mouse Anti-GIF Recombinant Antibody (139-1A11) (CBMAB-G3473-LY)

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Target: GIF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 139-1A11
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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