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GIF

This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq]

Full Name

gastric intrinsic factor (vitamin B synthesis)

Function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.

Biological Process

Cobalamin transport Source: UniProtKB
Cobalt ion transport Source: UniProtKB-KW

Cellular Location

Secreted

Involvement in disease

Hereditary intrinsic factor deficiency (IFD):
Autosomal recessive disorder characterized by megaloblastic anemia.

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Anti-GIF antibodies

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Mouse Anti-GIF Recombinant Antibody (CBLG1-1161) (CBMAB-G3482-LY)

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Target: GIF

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBLG1-1161

Application*: WB

Mouse Anti-GIF Recombinant Antibody (CBLG1-1160) (CBMAB-G3481-LY)

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Target: GIF

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1160

Application*: WB

Rabbit Anti-GIF Recombinant Antibody (CBLG1-1159) (CBMAB-G3480-LY)

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Target: GIF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1159

Application*: E, EC

Rabbit Anti-GIF Recombinant Antibody (CBLG1-1158) (CBMAB-G3479-LY)

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Target: GIF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1158

Application*: WB

Rabbit Anti-GIF Recombinant Antibody (CBLG1-1157) (CBMAB-G3478-LY)

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Target: GIF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1157

Application*: F

Mouse Anti-GIF Recombinant Antibody (1D9) (CBMAB-G3475-LY)

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Target: GIF

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D9

Application*: E, IF, IP

Mouse Anti-GIF Recombinant Antibody (139-1A11) (CBMAB-G3473-LY)

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Target: GIF

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 139-1A11

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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