GJB3

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
Full Name
gap junction protein, beta 3, 31kDa
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Biological Process
Cell-cell signaling Source: GO_Central
Cellular response to retinoic acid Source: Ensembl
In utero embryonic development Source: Ensembl
Placenta development Source: Ensembl
Skin development Source: Ensembl
Spermatogenesis Source: Ensembl
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Erythrokeratodermia variabilis et progressiva 1 (EKVP1):
A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
Deafness, autosomal dominant, 2B (DFNA2B):
A form of non-syndromic sensorineural deafness characterized by progressive high frequency hearing loss in adulthood, with milder expression in females.
Topology
Cytoplasmic: 1-20
Helical: 21-40
Extracellular: 41-75
Helical: 76-98
Cytoplasmic: 99-126
Helical: 127-149
Extracellular: 150-187
Helical: 188-210
Cytoplasmic: 211-270
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Anti-GJB3 antibodies

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Mouse Anti-GJB3 Recombinant Antibody (CBYY-C3126) (CBMAB-C4569-YY)

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Target: GJB3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C3126
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-GJB3 Recombinant Antibody (CBLG1-1206) (CBMAB-G3577-LY)

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Target: GJB3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1206
Application*: WB
Datasheet SDS

Mouse Anti-GJB3 Recombinant Antibody (CBLG1-1205) (CBMAB-G3576-LY)

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Target: GJB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1205
Application*: WB
Datasheet SDS

Mouse Anti-GJB3 Recombinant Antibody (3B4-1B3) (CBMAB-G3574-LY)

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Target: GJB3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B4-1B3
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-GJB3 Recombinant Antibody (CBLG1-110) (CBMAB-G0493-LY)

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Target: GJB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-110
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-GJB3 Recombinant Antibody (CBLG1-1205) (V2LY-1225-LY1385)

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Target: GJB3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1205
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-GJB3 Recombinant Antibody (CBLG1-110) (V2LY-1225-LY1384)

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Target: GJB3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-110
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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